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Comparison of 2 Free Light Chain Assays: Performance of the Free Light Chain Ratio as a Risk Factor for MGUS Progression.
Clin Chem
October 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Article Synopsis
- New immunoglobulin free light chain (FLC) assays, including FreeLite and Sebia, can be used interchangeably for diagnosing multiple myeloma and assessing risk in patients with MGUS, despite differing methodologies.
- A study of 923 MGUS patients showed that both assays had comparable effectiveness in predicting progression to plasma cell dyscrasias (PCD) over a median follow-up of 38 years.
- The Sebia assay offered improved risk stratification with a lower clinical decision point for patients with low FLC ratios, demonstrating the potential for its application alongside traditional models.
Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection.
Eur J Epidemiol
May 2024
Paris Institute for Transplantation and Organ Regeneration (PITOR), INSERM U970, Université Paris Cité, 56 rue Leblanc, 75015, Paris, France.
Article Synopsis
- The KTD-Innov study aims to address the lack of reliable biomarkers for kidney allograft rejection by analyzing a diverse group of kidney transplant recipients over one year, involving 733 participants across seven French centers.
- The study involved comprehensive data collection, including clinical, biological, immunological, and histological parameters, and developed a biobank with over 16,000 samples to facilitate future research.
- The findings reveal that the cumulative incidence of allograft rejection was 9.7% at one year, and the study population reflects the broader demographic of kidney transplant recipients in France and beyond, supporting its clinical relevance.
Evaluation of effects from hemoglobin variants on HbA measurements by different methods.
Clin Chem Lab Med
September 2024
Department of Clinical Laboratory, 74639 Beijing Chao-Yang Hospital, Capital Medical University, Beijing, P.R. China.
Objectives: The impact of seven hemoglobin variants (Hb Q-Thailand, Hb G-Honolulu, Hb Ube-2, Hb New York, Hb J-Bangkok, Hb G-Coushatta, and Hb E) on the outcome of HbA was investigated for six methods by comparing with liquid chromatography-tandem mass spectrometry (LC/MS/MS) reference method.
Methods: Twenty-nine normal and 112 variant samples were measured by LC/MS/MS, Sebia Capillarys 3 TERA, Intelligene Biosystems QuanTOF, Premier Hb9210, Arkray HA-8190V, Bio-Rad D-100, and Tosoh G11, then evaluated for correlation, consistency, and mean relative bias among six methods. The lowest biological variation bias of ±2.
Clinical specificity of two assays for immunoglobulin kappa and lambda free light chains.
Clin Chem Lab Med
April 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Objectives: Free light chain (FLC) assays and the ratio of κ/λ are recommended for diagnosis, prognosis and monitoring of plasma cell dyscrasias (PCD). Limited data exists on FLC clinical specificity in patients diagnosed with other conditions.
Methods: We assessed the κ, λ, and κ/λ FLC ratio using the FreeLite assay and the Sebia FLC ELISA assay in 176 patients with clinical presentations of fatigue, anemia, polyclonal hypergammaglobulinemia, joint disorders, kidney disease and non PCD-cancers with no monoclonal protein observed on serum protein electrophoresis or MASS-FIX immunoglobulin isotyping.
Circulating Metabolites and Cardiovascular Disease in Asians with Chronic Kidney Disease.
Cardiorenal Med
December 2023
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Introduction: Chronic kidney disease (CKD) is a growing public health problem, with significant burden of cardiovascular disease and mortality. The risk of cardiovascular disease in CKD is elevated beyond that predicted by traditional cardiovascular risk factors, suggesting that other factors may account for this increased risk. Through metabolic profiling, this study aimed to investigate the associations between serum metabolites and prevalent cardiovascular disease in Asian patients with CKD to provide insights into the complex interactions between metabolism, cardiovascular disease and CKD.
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