Background And Objectives: We present the case of a 67-year-old man who developed encephalopathy, headaches, and seizure activity after initiating treatment with the novel tyrosine kinase inhibitor, sitravatinib.
Methods: The patient was identified in routine clinical practice.
Results: Brain MRI revealed lobar microhemorrhages and bihemispheric vasogenic edema. The patient met the criteria for probable cerebral amyloid angiopathy-related inflammation (CAA-ri) and responded favorably to high-dose methylprednisolone.
Discussion: This report of neurologic autoimmunity in a patient receiving sitravatinib opens new lines of inquiry into the pathophysiology of CAA-ri. We emphasize the importance of early recognition and treatment of CAA-ri among patients receiving immunomodulatory chemotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208403 | PMC |
| http://dx.doi.org/10.1212/CPJ.0000000000001162 | DOI Listing |
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