AI Article Synopsis
- The study focused on pediatric Ebola virus disease (EVD) survivors in Sierra Leone, highlighting their risks for eye disease and mental health issues compared to close contacts.
- Results showed a higher prevalence of eye disorders, like uveitis, in EVD survivors (10.8%) versus close contacts (1.7%). Additionally, nearly half of the survivors had some form of eye disease at the time of study.
- Findings revealed that both health-related and vision-related quality-of-life for EVD survivors were low, indicating a need for comprehensive approaches to address their ongoing health challenges.
Article Abstract
Background: Ebola virus disease (EVD) outbreaks in West Africa (2013-2016) and the Democratic Republic of Congo (2018-2020) have resulted in thousands of EVD survivors who remain at-risk for survivor sequelae. While EVD survivorship has been broadly reported in adult populations, pediatric EVD survivors are under-represented. In this cross-sectional study, we investigated the prevalence of eye disease, health-related quality-of-life, vision-related quality-of-life, and the burden of mental illness among pediatric EVD survivors in Sierra Leone.
Methods: Twenty-three pediatric EVD survivors and 58 EVD close contacts were enrolled. Participants underwent a comprehensive ophthalmic examination and completed the following surveys: Pediatric Quality of Life Inventory Version 4.0, Effect of Youngsters Eyesight on Quality-of-Life, and the Revised Child Anxiety and Depression Scale.
Findings: A higher prevalence of uveitis was observed in EVD survivor eyes (10·8%) cohort compared to close contacts eyes (1·7%, p=0·03). Overall, 47·8% of EVD survivor eyes and 31·9% of close contact eyes presented with an eye disease at the time of our study (p=0·25). Individuals diagnosed with an ocular complication had poorer vision-related quality-of-life (p=0·02).
Interpretation: Both health related quality-of-life and vision-related quality-of-life were poor among EVD survivors and close contacts. The high prevalence of eye disease associated with reduced vision health, suggests that cross-disciplinary approaches are needed to address the unmet needs of EVD survivors.
Funding: National Institutes of Health R01 EY029594, K23 EY030158; National Eye Institute; Research to Prevent Blindness (Emory Eye Center); Marcus Foundation Combating Childhood Illness; Emory Global Health Institute; Stanley M. Truhlsen Family Foundation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167858 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2022.101483 | DOI Listing |
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