Keratoconus: A Biomechanical Perspective.

Purpose: The relevance of corneal biomechanics and the importance of including it in the clinical assessment of corneal ectasias are being increasingly recognized. The connection between corneal ultrastructure, biomechanical properties, and optical function is exemplified by a condition like keratoconus. Biomechanical instability is seen as the underlying basis for the secondary morphological changes in the cornea. Asymmetric biomechanical weakening is believed to drive progressive corneal steepening and thinning. Biomechanical strengthening is the principle of collagen crosslinking that has been shown to effectively arrest progression of the keratoconus. Corneal biomechanics has therefore ignited the interest of researchers and clinicians alike and has given us new insights into the cause and course of the disease. This article is an overview of the extensive work published, predominantly in the last two decades, on the biomechanical aspect of keratoconus.

Methods: Published articles on corneal biomechanics in the specific context of keratoconus were reviewed, based on an electronic search using PubMed, Elsevier, and Science Direct. The search terms used included "Corneal Biomechanics," "Mechanical properties of the cornea," "Corneal ultrastructure," "Corneal Collagen," and "Keratoconus". Articles pertaining to refractive surgery, keratoplasty, collagen crosslinking, or intrastromal rings were excluded.

Results: The electronic search revealed more than 500 articles, from which 80 were chosen for this article.

Conclusions: The structural and organizational pattern of the corneal stroma determines its mechanical properties and are responsible for the maintenance of the normal shape and function of the cornea. Changes in the ultrastructure are responsible for the biomechanical instability that leads to corneal ectasia. As non-invasive methods for evaluating corneal biomechanics evolve, our ability to diagnose subclinical keratoconus will improve, allowing identification of patients at risk to develop ectasia and to allow early treatment to arrest progression of the disease.