AI Article Synopsis
- Faecal microbiota transplantation (FMT) is gaining popularity as a treatment for various diseases, including autoimmune, gastrointestinal, and neurological conditions, and has shown effectiveness as a second-line treatment for Clostridium difficile infection (CDI).
- FMT shows potential in improving bowel diseases like ulcerative colitis and may also help influence chronic kidney disease (CKD) by correcting issues in the gut-kidney axis.
- Given the limited treatment options for CKD, FMT could provide a promising therapy to address gut dysbiosis and improve patient outcomes.
Article Abstract
Faecal microbiota transplantation (FMT) has attracted increasing attention as an intervention in many clinical conditions, including autoimmune, enteroendocrine, gastroenterological, and neurological diseases. For years, FMT has been an effective second-line treatment for infection (CDI) with beneficial outcomes. FMT is also promising in improving bowel diseases, such as ulcerative colitis (UC). Pre-clinical and clinical studies suggest that this microbiota-based intervention may influence the development and progression of chronic kidney disease (CKD) via modifying a dysregulated gut-kidney axis. Despite the high morbidity and mortality due to CKD, there are limited options for treatment until end-stage kidney disease occurs, which results in death, dialysis, or kidney transplantation. This imposes a significant financial and health burden on the individual, their families and careers, and the health system. Recent studies have suggested that strategies to reverse gut dysbiosis using FMT are a promising therapy in CKD. This review summarises the preclinical and clinical evidence and postulates the potential therapeutic effect of FMT in the management of CKD.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228952 | PMC |
| http://dx.doi.org/10.3390/nu14122528 | DOI Listing |
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