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Evasion of Antimicrobial Activity in by Target Site Modifications: An Effective Resistance Mechanism. | LitMetric

Evasion of Antimicrobial Activity in by Target Site Modifications: An Effective Resistance Mechanism.

Int J Mol Sci

Laboratorio de Investigación Clínica y Ambiental, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Casco de Santo Tomas, Miguel Hidalgo, Ciudad de Mexico 11340, Mexico.

Published: June 2022

AI Article Synopsis

Article Abstract

is a Gram-negative bacillus that causes multiple infections that can become severe, mainly in hospitalized patients. Its high ability to persist on abiotic surfaces and to resist stressors, together with its high genomic plasticity, make it a remarkable pathogen. Currently, the isolation of strains with high antimicrobial resistance profiles has gained relevance, which complicates patient treatment and prognosis. This resistance capacity is generated by various mechanisms, including the modification of the target site where antimicrobial action is directed. This mechanism is mainly generated by genetic mutations and contributes to resistance against a wide variety of antimicrobials, such as β-lactams, macrolides, fluoroquinolones, aminoglycosides, among others, including polymyxin resistance, which includes colistin, a rescue antimicrobial used in the treatment of multidrug-resistant strains of and other Gram-negative bacteria. Therefore, the aim of this review is to provide a detailed and up-to-date description of antimicrobial resistance mediated by the target site modification in , as well as to detail the therapeutic options available to fight infections caused by this bacterium.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223528PMC
http://dx.doi.org/10.3390/ijms23126582DOI Listing

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