AI Article Synopsis
- The study focuses on complex Mycobacterium tuberculosis Lineage 3 (L3) strains, which are prevalent in regions with high tuberculosis rates, analyzing 2682 strains from 38 countries.
- Researchers used advanced techniques like MIRU-VNTR genotyping and whole-genome sequencing to explore the genetic diversity and population structure of L3 strains across five continents.
- Findings indicate that L3 strains originated in Southern Asia and later spread to North-East and East Africa, offering insights that could aid in the development of new treatments and vaccines for tuberculosis.
Article Abstract
complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeats genotyping (MIRU-VNTR) and drug susceptibility testing. We further combined whole-genome sequencing (WGS) and phylogeographic analysis for 373 strains representing the global L3 genetic diversity. Ancestral state reconstruction confirmed that the origin of L3 strains is located in Southern Asia and further revealed multiple independent introduction events into North-East and East Africa. This study provides a systematic understanding of the global diversity of L3 strains and reports phylogenetic variations that could inform clinical trials which evaluate the effectivity of new drugs/regimens or vaccine candidates.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222951 | PMC |
| http://dx.doi.org/10.3390/genes13060990 | DOI Listing |
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