Our aim was to examine whether vanadium (IV) corrects alterations in zinc, copper and manganese homeostasis, observed in streptozotocin-induced hyperglycemic rats, and whether such changes are related to divalent metal transporter 1 (DMT1) mRNA expression, and antioxidant and proinflammatory parameters. Four groups of Wistar rats were examined: control; hyperglycemic (H); hyperglycemic treated with 1 mg V/day (HV); and hyperglycemic treated with 3 mg V/day (HVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(IV) for five weeks. Zinc, copper and manganese were measured in food, excreta, serum and tissues. DMT1 mRNA expression was quantified in the liver. Hyperglycemic rats showed increased Zn and Cu absorption and content in the liver, serum, kidneys and femurs; DMT1 expression also increased (p < 0.05 in all cases). HV rats showed no changes compared to H rats other than decreased DMT1 expression (p < 0.05). In the HVH group, decreased absorption and tissular content of studied elements (p < 0.05 in all cases) and DMT1 expression compared to H (p < 0.05) were observed. Liver zinc, copper and manganese content correlated positively with glutathione peroxidase activity and negatively with catalase activity (p < 0.05 in both cases). In conclusion, treatment with 3 mg V/d reverted the alterations in zinc and copper homeostasis caused by hyperglycemia, possibly facilitated by decreased DMT1 expression.
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http://dx.doi.org/10.3390/biology11060814 | DOI Listing |
Biol Trace Elem Res
December 2024
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
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School of Public Administration, Hohai University, Nanjing, 211000, China; Observation Research Station of Land Ecology and Land Use in the Yangtze River Delta, Ministry of Natural Resources, Nanjing, 210009, China. Electronic address:
Due to the rapid increase in industrial and urban areas, environmental pollution is increasing worldwide, which is causing unwanted changes in air, water, and soil at biological, physical, as well as chemical levels that ultimately causing the negative effects in living things because of toxic level of chromium (Cr). However, nanotechnology is capturing great interest worldwide due to their stirring applications in various fields. For this purpose, a pot experiment was conducted to examine plant growth and exo-physiology in rice (Oryza sativa L.
View Article and Find Full Text PDFMol Biol Rep
December 2024
Postgraduate Program in Animal Bioscience, Federal University of Jataí, Jataí, Goiás, Brazil.
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View Article and Find Full Text PDFLangmuir
December 2024
School of Material Science & Engineering, State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin 300387, China.
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View Article and Find Full Text PDFSci Total Environ
December 2024
Department of Physical Geography, University of Göttingen, 37077 Göttingen, Germany. Electronic address:
Potentially toxic elements (PTEs) in soils threaten human health through several exposure pathways. However, health risks posed by PTEs in soils in developing countries have not yet been comprehensively investigated. Thus, such countries lack important information that is needed to implement sustainable solutions.
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