We present a mathematical model of key glucose metabolic pathways in two cells of the human retina: the rods and the retinal pigmented epithelium (RPE). Computational simulations of glucose transporter 1 (GLUT1) inhibition in the model accurately reproduce experimental data from conditional knockout mice and reveal that modification of GLUT1 expression levels of both cells differentially impacts their metabolism. We hypothesize that, under glucose scarcity, the RPE's energy producing pathways are altered in order to preserve its functionality, impacting the photoreceptors' outer segment renewal. On the other hand, when glucose is limited in the rods, aerobic glycolysis is preserved, which maintains the lactate contribution to the RPE.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226191 | PMC |
| http://dx.doi.org/10.1038/s41598-022-13950-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China.
Background: Personality traits, especially neuroticism, can influence susceptibility to dementia. Although social contact can mitigate stress and risk of dementia, the extent to which social contact can mitigate excess risk associated with neuroticism remains unclear. The objective of study was to investigate changes in neuroticism-associated excess risk of dementia arising from different levels of social contact.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Recognizing Alzheimer's disease (AD) early is essential for enhancing patient outcomes. Therefore this research focused on exploring indicators of AD by investigating the role of declining financial capacity (FC) in predicting objetive cognitive impairment (OCI).
Method: We analyzed participants without OCI in Mini-mental state examination (MMSE, Table 1) or Clinical Dementia Rating-Sum of Boxes (CDR-SB, Table 2) scores from the ADNI database.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University at Albany, SUNY, Albany, NY, USA.
Background: The experience of spouse caregivers of individuals with Alzheimer's Disease (AD) is marked by witnessing the gradual cognitive decline of their loved ones. This journey transforms the nature of their marital relationship, evolving from mutual interdependence to a more unilateral caregiving role. Despite this significant shift, the specific phenomenon of self-loss among these caregivers remains underexplored in academic research.
View Article and Find Full Text PDFThe Elusive Ternary Intermediates of Chiral Phosphoric Acids in Ion Pair Catalysis─Structures, Conformations, and Aggregation.
J Am Chem Soc
January 2025
Institute of Organic Chemistry, University Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
In ion-pair catalysis, the last intermediate structures prior to the stereoselective transition states are of special importance for predictive models due to the high isomerization barrier between - and -substrate double bonds connecting ground and transition state energies. However, in prior experimental investigations of chiral phosphoric acids (CPA) solely the early intermediates could be investigated while the key intermediate remained elusive. In this study, the first experimental structural and conformational insights into ternary complexes with CPAs are presented using a special combination of low temperature and relaxation optimized N HSQC-NOESY NMR spectroscopy to enhance sensitivity.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
Hanyang University, Seoul, Seoul, Korea, Republic of (South).
In the treatment of Alzheimer's disease (AD), traditional 40Hz gamma wave stimulation, while effective in improving cognitive function, has been limited by the lengthy duration of treatment. To address this, our study sought to enhance the time efficiency of 40Hz stimulation by utilizing intermittent theta-burst stimulation (iTBS) as a pretreatment. Experiments were conducted on AD mouse models, divided into four groups: no stimulation, 40Hz stimulation only, iTBS stimulation only, and combined iTBS and 40Hz stimulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!