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The vectors went in two-by-two: Transduction efficiency and tolerability of dual and triple rAAV vector delivery following intravitreal injection for genome-editing applications.
Exp Eye Res
December 2024
Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, WI, 53226, USA; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, WI, 53226, USA. Electronic address:
Genome or prime editing has become a promising tool for the treatment of hereditary disorders affecting the inner retina, such as dominant optic neuropathies. In vivo delivery of gene editors, such as Cas9, is typically achieved using recombinant adeno-associated virus (rAAV) vectors, which have a broad range of cellular tropisms and are well tolerated following intravitreal administration. Owing to the large size of gene editing constructs and the limited carrying capacity of rAAV (<5.
View Article and Find Full Text PDFRelationship between autism spectrum disorder and peripapillary intraretinal layer thickness: a pediatric retrospective cross-sectional study.
Quant Imaging Med Surg
December 2024
Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Background: Autism spectrum disorder (ASD) often presents with atypical visual processing, prompting investigation into its connection with retinal features. This study aimed to (I) compare intraretinal layer thickness in the peripapillary region between ASD and neurotypical (NT) groups, (II) assess associations between intraretinal layer thickness and clinical parameters (social functioning and cognitive levels) in ASD subjects, and (III) evaluate the potential of intraretinal layer thickness as a biomarker for ASD.
Methods: Participants were recruited through convenience sampling from the Children's Mental Health Research Center at The Affiliated Brain Hospital of Nanjing Medical University and the Department of Ophthalmology at The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, between December 2019 and August 2023.
Morphological and functional observations of a novel model of retinal ischemia injury induced by bilateral carotid artery stenosis in mice.
Int J Ophthalmol
December 2024
Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Aim: To investigate the features of retinal ischemic injuries in a novel mouse model with bilateral carotid artery stenosis (BCAS).
Methods: BCAS was induced with microcoil implantation in 6-8-week-old C57BL6 mice. Cerebral blood flow was monitored at 2, 7, and 28d postoperatively.
New frontiers in retinal transplantation.
World J Transplant
December 2024
Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
New frontiers about retinal cell transplantation for retinal degenerative diseases start from the idea that acting on stem cells can help regenerate retinal layers and establish new synapses among retinal cells. Deficiency or alterations of synaptic input and neurotrophic factors result in trans-neuronal degeneration of the inner retinal cells. Thus, the disruption of photoreceptors takes place.
View Article and Find Full Text PDFClinical characteristics and risk factors of bacillary layer detachment in central serous chorioretinopathy: a comparative multicenter study.
Int J Retina Vitreous
December 2024
Federal University of São Paulo, São Paulo, Brazil.
Background: Central serous chorioretinopathy (CSC) is marked by serous retinal detachments caused by fluid leakage from the retinal pigment epithelium, often associated with stress, psychiatric disorders and the use of corticosteroids. This study aims to investigate the clinical and systemic characteristics associated with BALAD in patients with CSC, comparing those with and without BALAD to clarify its function as a biomarker of CSC severity and improve diagnostic and treatment approaches.
Purpose: Compare the clinical characteristics, risk factors, and optical coherence tomography (OCT) findings in patients with Central Serous Chorioretinopathy (CSC) with and without Bacillary Layer Detachment (BALAD), and to identify the distinguishing features and associated conditions of CSC with BALAD.
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