Amplification of bla mediated by ISCR1 confers hyperresistance to carbapenem.

J Glob Antimicrob Resist

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. Electronic address:

Published: September 2022

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jgar.2022.06.015DOI Listing

Publication Analysis

Top Keywords

amplification bla
4
bla mediated
4
mediated iscr1
4
iscr1 confers
4
confers hyperresistance
4
hyperresistance carbapenem
4
amplification
1
mediated
1
iscr1
1
confers
1

Similar Publications

Background: has developed resistance to almost all the antimalarial drugs currently in use. This resistance has been and remains one of the greatest threats to the control and elimination of malaria. The use of molecular markers of resistance to monitor the emergence and spread of antimalarial drug-resistant parasite strains has proved highly effective.

View Article and Find Full Text PDF

Multiple mechanisms mediate aztreonam-avibactam resistance in Klebsiella pneumoniae: driven by KPC-2 and OmpK36 mutations.

Int J Antimicrob Agents

December 2024

Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China. Electronic address:

Aztreonam-avibactam (ATM-AVI) is a promising β-lactam/β-lactamase inhibitor combination with an antimicrobial spectrum covering serine carbapenemase- or metallo-β-lactamase-producing Enterobacterales. Although ATM-AVI has not been widely used in clinical practice, resistance to it in Escherichia coli has been widely reported. In this study, we investigated an ATM-AVI-resistant Klebsiella pneumoniae strain, designated as 1705R, derived from K.

View Article and Find Full Text PDF

Antimicrobial resistance (AMR) is a growing global concern and poses a significant threat to public health. The emergence of multidrug-resistant organisms, including , also presents a risk of transmission to humans through the food chain, including milk. This study aimed to investigate the prevalence of in raw milk in the Chattogram metropolitan area (CMA) of Bangladesh and their phenotypic and genotypic antimicrobial resistance patterns.

View Article and Find Full Text PDF

Genetic profiling of multidrug-resistant from a tertiary care center in Malaysia.

Microbiol Spectr

December 2024

Institute for Medical Molecular Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sg. Buloh Campus, Jalan Hospital, Sg. Buloh, Selangor, Malaysia.

Genetic characterization of multidrug-resistant (MDR) remains scarce in Malaysia. This study aimed to characterize antibiotic resistance, genomic location, and genetic relatedness among the isolates obtained from a tertiary hospital in Malaysia. A total of 128 MDR isolates were collected from patients admitted to various wards (intensive care unit [ICU], neonatal intensive care unit, coronary care unit, high dependency ward [HDW], and general wards).

View Article and Find Full Text PDF

Klebsiella pneumoniae carbapenemase-producing Pseudomonas aeruginosa (KPC-PA) isolates have quickly expanded in China, especially the high-risk clone ST463. We aimed to explore the evolution of KPC-related plasmids driving ST463 clone success. Whole-genome sequencing of 1258 clinical P.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!