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http://dx.doi.org/10.1073/pnas.2207180119 | DOI Listing |
Proc Natl Acad Sci U S A
June 2022
Structural Biochemistry Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.
Nat Commun
April 2022
Department of Biosciences, Rice University, Houston, TX, 77005, USA.
Error-free replication of DNA is essential for life. Despite the proofreading capability of several polymerases, intrinsic polymerase fidelity is in general much higher than what base-pairing energies can provide. Although researchers have investigated this long-standing question with kinetics, structural determination, and computational simulations, the structural factors that dictate polymerase fidelity are not fully resolved.
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