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Article Synopsis
  • The World Health Assembly set six global nutrition targets (GNTs) in 2012 to improve maternal and child health, but there has been no comprehensive report detailing progress from 2012 to 2021.
  • A study evaluated the prevalence and impact of these nutrition targets across 204 countries using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 and projected future trends up to 2050.
  • By 2021, only a few countries met some GNTs; most showed increased child overweight and notable decreases in female anaemia, highlighting a connection between societal development status and nutritional challenges.
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Gasping for air: HIF2α in asthma.

Immunity

December 2024

Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

Despite protective roles in various type of infection and in would healing, T helper (Th)2 cells are drivers of inflammation in allergic asthma. In this issue of Immunity, Zou et al. demonstrate the crucial involvement of hypoxia inducible factor (HIF)2α in promoting the differentiation of inflammatory Th2 cells, suggesting HIF2α as a promising therapeutic target for the treatment of allergic asthma.

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The increase in wildfires and bushfires due to climate change means that more people, including pregnant women and their fetuses will be exposed to landscape fire smoke. Although there is evidence to suggest that pregnancy landscape fire exposure is associated with lower birth weight, preterm birth and pregnancy loss, there is a lack of information on many other perinatal outcomes, as well as information on subsequent respiratory outcomes in children. Furthermore, due to the generally short term (hours/days) and intermittent nature of landscape fire smoke exposure, the knowledge to date has largely relied on natural experiments and ecological studies which can be subject to misclassification of exposure and a lack of precision.

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