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Women's preferences for testing to predict breast cancer risk - a discrete choice experiment.
J Transl Med
January 2025
Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Republic of Singapore.
Background: Risk-based breast cancer screening offers a more targeted and potentially cost-effective approach in cancer detection compared to age-based screening. This study aims to understand women's preferences and willingness for undergoing risk assessment tests.
Methods: A discrete choice experiment (DCE) was conducted.
Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis.
BMC Med
January 2025
Department of Cardiothoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Background: Current research underscores the need to better understand the pathogenic mechanisms and treatment strategies for idiopathic pulmonary fibrosis (IPF). This study aimed to identify key targets involved in the progression of IPF.
Methods: We employed Mendelian randomization (MR) with three genome-wide association studies and four quantitative trait loci datasets to identify key driver genes for IPF.
Prehospital lactate analysis in suspected sepsis improves detection of patients with increased mortality risk: an observational study.
Crit Care
January 2025
Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Background: Rapid, adequate treatment is crucial to reduce mortality in sepsis. Risk stratification scores used at emergency departments (ED) are limited in detecting all septic patients with increased mortality risk. We assessed whether the addition of prehospital lactate analysis to clinical risk stratification tools improves detection of patients with increased risk for rapid deterioration and death in sepsis.
View Article and Find Full Text PDFAdding salt to foods and risk of incident depression and anxiety.
BMC Med
January 2025
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Haidian District, 38 Xueyuan Road, Beijing, 100191, China.
Background: Diet is a well-known determinant of mental health outcomes. However, epidemiologic evidence on salt consumption with the risk of developing depression and anxiety is still very limited. This study aimed to examine the association between adding salt to foods and incident depression and anxiety longitudinally.
View Article and Find Full Text PDFOxidative stress and retinopathy: evidence from epidemiological studies.
J Transl Med
January 2025
Cancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
Background: Previous studies have suggested oxidative stress may play a key role in the pathogenesis of retinopathy, while evidence from observational studies directly linking oxidative biomarkers to clinically relevant outcomes has been limited. This study aims to investigate the association between oxidative balance score (OBS) and prevalence of retinopathy in a nationally representative sample of U.S.
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