AI Article Synopsis
- Bioactive glasses are engineered as porous templates to promote 3D bone growth, and this research compares their effectiveness to other materials like powders and granules.
- Using scanning electron microscopy and energy dispersive spectroscopy, the study confirmed that these silicate bioactive glass scaffolds can form apatite, which is essential for bonding with bone in living organisms.
- The scaffolds demonstrated significant bone regeneration in rabbit femurs, showing full resorption and new bone formation within 6 months, indicating their potential for future clinical use in bone tissue engineering.
Article Abstract
Bioactive glasses are often designed as porous implantable templates in which newly-formed bone can grow in three dimensions (3D). This research work aims to investigate the bone regenerative capability of silicate bioactive glass scaffolds produced by robocasting in comparison with powder and granule-like materials (oxide system: 47.5SiO-10NaO-10KO-10MgO-20CaO-2.5PO, mol.%). Morphological and compositional analyses performed by scanning electron microscopy (SEM), combined with energy dispersive spectroscopy (EDS) after the bioactivity studies in a simulated body fluid (SBF) confirmed the apatite-forming ability of the scaffolds, which is key to allowing bone-bonding in vivo. The scaffolds exhibited a clear osteogenic effect upon implantation in rabbit femur and underwent gradual resorption followed by ossification. Full resorption in favor of new bone growth was achieved within 6 months. Osseous defect healing was accompanied by the formation of mature bone with abundant osteocytes and bone marrow cells. These in vivo results support the scaffold's suitability for application in bone tissue engineering and show promise for potential translation to clinical assessment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224601 | PMC |
| http://dx.doi.org/10.3390/jfb13020074 | DOI Listing |
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