AI Article Synopsis
- The study investigated the effects of labetalol therapy, alone or combined with a diuretic (oxodolin) and a low-sodium diet, on patients with severe hypertension.
- Results indicated that combining treatments led to a more significant decrease in blood pressure, especially in patients with diastolic blood pressure over 110 mm Hg.
- The combination therapy allowed for a reduction of 25-45% in the required dosage of labetalol, and the low-sodium diet with potassium substitutes was well received by the patients.
Article Abstract
Hypotensive activity of labetalol therapy alone or in combination with the diuretic agent oxodolin or with low-sodium diet (about 110 mmol/day) and potassium cooking salt substitute "Sanasol" (60% sodium chloride, ammonium chloride, calcium gluconate, magnesium asparaginate, etc.) was studied in 67 patients with second- or third-stage essential hypertension and 14 patients with nephrogenic hypertension. Central hemodynamic changes were assessed by means of radiocardiography and tetrapolar rheography. Combined treatment had better hypotensive effect in moderate and severe hypertension (diastolic arterial BP above 110 mm Hg). The diuretic-labetalol combination made possible a 25-45% reduction in the adrenoblocker dose. The effect of combined hypotensive treatment was similar in patients with different central hemodynamic types. Low-sodium diet with potassium substitute was well tolerated by the patients.
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