This systematic review aimed to outline the outcome of () variants on the effects of anesthetic and analgesic agents used in various procedures. Literature was obtained from reliable, established databases and reference tracking. Efficacy and side/adverse effects of anesthetic and analgesic drugs intraoperatively or within 48 h postsurgery were the key outcome measures for all populations. Animal studies were excluded. Twenty-nine studies were chosen for inclusion. In association with the efficacy and safety of anesthetic and analgesic agents, gene polymorphism in displayed a strong correlation in reduced analgesic effect and protection against adverse reactions. This systematic review summarized the correlation between genetic polymorphism in the gene and anesthetic/analgesic effects.
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| http://dx.doi.org/10.2217/pgs-2022-0042 | DOI Listing |
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