AI Article Synopsis
- Over 50% of knee ligament injuries are ACL injuries, which can lead to instability and early osteoarthritis but preserving ACL remnants helps maintain knee stability.
- The study evaluates mechanoreceptor expression in ACL remnants from 10 tibial and 10 femoral samples using immunohistochemistry to aid surgical visualization while preserving these remnants.
- Results show that type 2 remnants are the most common, with no significant difference in mechanoreceptor expression between femoral and tibial remnants, highlighting the importance of preserving both for successful ACL reconstruction.
Article Abstract
Introductions: More than 50% of knee ligament injuries are anterior cruciate ligament (ACL) injuries. The injury can lead to instability and osteochondral damage which in turn leads to early osteoarthritis. ACL remnant contains sensory nerve cells and mechanoreceptors which are useful for reinnervation of the graft and maintaining the knee stability. However, ACL remnant preservation can interfere the visualization during surgery. The number of mechanoreceptors in the ACL remnant of the tibia and femur have to be determined to help the surgeon get better visualization and at the same time preserve the mechanoreceptors in the ACL remnant during reconstruction.
Methods: This study aims to evaluate semi-quantitatively the expression of mechanoreceptors in ACL remnant in the tibia and femur using immunohistochemistry. From January to April 2021, 10 femoral and 10 tibial remnants was obtained from ACL injury patient who received arthroscopic ACL reconstruction. Both of them were analysed using immunohistochemistry with S100 and NFL antibodies. The type of remnant was recorded and the expression of the mechanoreceptor was observed under the microscope.
Results: The most common type of ACL remnant recorded were type 2 (50%), followed by type 1 (40%) and type 4 (10%). There were no significant differences in the expression of mechanoreceptors between femoral remnant and tibial remnant (p = 0.45 and p = 0.134).
Conclusions: No difference in the expression of mechanoreceptors of femoral and tibial ACL remnant. Preservation of both femoral and tibial remnants is important in ACL reconstruction surgery.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207111 | PMC |
| http://dx.doi.org/10.1016/j.amsu.2022.103849 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Purpose: Absorbable interference screws for anterior cruciate ligament reconstruction (ACLR) can lead to tunnel widening and cyst formation. The Biosure Regenesorb interference screw (Smith & Nephew). has been developed with an optimised calcium phosphate/polymer composition to promote bone formation during resorption.
View Article and Find Full Text PDFHistological Changes in the Blood Vessels of Ruptured Human Anterior Cruciate Ligaments.
Cureus
September 2024
Orthopaedics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.
Article Synopsis
- ACL ruptures are common sports injuries with poor healing due to low blood supply, often leading to post-surgery osteoarthritis 10-15 years later.
- Recent research suggests that the tibial remnants of the ACL have the potential to heal and that their vascular characteristics are important for new surgical methods that preserve these remnants.
- This study evaluated the blood vessel density and characteristics in ruptured ACL remnants of 24 patients but found no significant correlation between injury duration and blood vessel density across different groups.
Histological Changes in Ruptured Anterior Cruciate Ligament: A Comparative, Prospective, Observational Study in Different Age Groups and Time of Presentation Since Injury.
Cureus
September 2024
Orthopedics, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Anterior cruciate ligament (ACL) injury is one of the most common sports-related injuries. Because of its intra-capsular location, it has very little chance of healing following injury. The causes of poor healing of ACL tears are mostly due to poor vascularity, disorganized collagen bundles, insufficient myofibroblast proliferation, etc.
View Article and Find Full Text PDFIncreased vascular endothelial growth factor expression is associated with cruciate ligament degeneration in patients with osteoarthritis of the knee.
BMC Musculoskelet Disord
October 2024
Department of Orthopaedic Surgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Article Synopsis
- This study explored how vascular endothelial growth factor (VEGF) is expressed in cruciate ligaments from osteoarthritis (OA) patients, suggesting a link between VEGF levels and ligament degeneration.
- Samples from anterior cruciate ligaments (ACLs) from trauma patients and ACLs and posterior cruciate ligaments (PCLs) from OA patients were examined for VEGF and tenomodulin expression.
- Findings indicated that higher VEGF expression was connected to greater degeneration in ACLs from OA patients, while tenomodulin levels decreased with increased degeneration.
Younger age, longer delay to surgery and meniscal tears are associated with a smaller ACL remnant: An analysis from the registry of the Francophone Arthroscopic Society.
Knee Surg Sports Traumatol Arthrosc
September 2024
Ramsay Santé, Hôpital privé Jean Mermoz, Centre Orthopédique Santy, FIFA Medical Center of Excellence, Lyon, France.
Article Synopsis
- The study aimed to identify factors affecting the volume of ACL remnants in patients undergoing ACL surgery, hypothesizing that younger age and longer wait times for surgery were key contributors.
- A total of 1565 patients were analyzed, excluding revisions and incomplete data, focusing on demographics, time to surgery, and presence of meniscal or cartilage injuries.
- Results indicated that younger patients (under 30), those waiting over a year for surgery, and individuals with meniscal tears had significantly lower ACL remnant volumes, suggesting these factors should be considered in surgical planning.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!