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| http://dx.doi.org/10.1073/pnas.2205630119 | DOI Listing |
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Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011-2018.
Front Nutr
January 2025
Department of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, China.
Background: Muscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle mass index (ASMI) and phenotypic age(PhenoAge), while examining the mediating role of systemic inflammation.
Methods: The analysis included 7,440 participants from the NHANES 2011-2018.
The eukaryotic genome is broadly transcribed by RNA polymerase II (RNAPII) to produce protein-coding messenger RNAs (mRNAs) and a repertoire of non-coding RNAs (ncRNAs). Whereas RNAPII is very processive during mRNA transcription, it terminates rapidly during synthesis of many ncRNAs, particularly those that arise opportunistically from accessible chromatin at gene promoters or enhancers. The divergent fates of mRNA versus ncRNA species raise many questions about how RNAPII and associated machineries discriminate functional from spurious transcription.
View Article and Find Full Text PDFImpact of Shale Barriers on Steam Chamber Evolution and Heat Distribution during the Rising Stage of Steam-Assisted Gravity Drainage (SAGD).
ACS Omega
January 2025
State Key Laboratory of Offshore Oil Exploitation, Beijing 100028, China.
Shale barriers negatively impact thermal recovery processes of oil sand or ultraheavy oil, particularly during the rising stage of SAGD, by affecting oil flow, steam chamber evolution, and heat distribution. Existing mathematical models for the rising stage of SAGD often overlook the influence of shale barriers on the evolution of the steam chamber and heat distribution. This study includes experiments to investigate the impact of a single shale barrier above the production well during the rising stage of the SAGD.
View Article and Find Full Text PDFUltra-Fast Moisture Sensor for Respiratory Cycle Monitoring and Non-Contact Sensing Applications.
Adv Mater
January 2025
Henry Royce Institute and Photon Science Institute, Department of Electrical and Electronic Engineering, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
As human-machine interface hardware advances, better sensors are required to detect signals from different stimuli. Among numerous technologies, humidity sensors are critical for applications across different sectors, including environmental monitoring, food production, agriculture, and healthcare. Current humidity sensors rely on materials that absorb moisture, which can take some time to equilibrate with the surrounding environment, thus slowing their temporal response and limiting their applications.
View Article and Find Full Text PDFAge-dependent increase in apoptosis is associated with dysregulation of miR-92a/Akt/mTOR and NF-κB signaling pathways in male rats.
Neurosci Lett
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Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:
Brain aging is the leading risk factor for most neurodegenerative diseases and has been linked with high rates of neuron loss. Thus, identifying molecular mechanisms underlying neuron loss and pharmacological modulation may be of great importance for slowing or preventing age-related diseases. Herein, we investigated the roles of miR-92a, Akt, mTOR, and NF-κB in age-associated apoptosis in the hippocampus (a critical structure involved in brain aging) of male rats alone and in combination with prazosin.
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