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Nivolumab-Induced Limbic Encephalitis Associated with Glutamic Acid Decarboxylase 65 Antibodies.
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July 2023
McGill University, Montreal, QC, Canada.
Very high-dose methylprednisolone for treatment of nivolumab-induced limbic encephalitis: A case report.
J Oncol Pharm Pract
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Department of Pharmacy, Centre hospitalier de l'Universite de Montreal, Montreal, Canada.
Introduction: Nivolumab is a programmed death 1 (PD-1) inhibitor approved by the Food and Drug Administration (FDA) for the treatment of eight different cancers including metastatic melanoma. Immune checkpoint blockade may lead to a range of neurologic immune-related adverse events (irAEs) with severity varying from mild to life-threatening, including encephalitis.
Case Report: We describe a case of a 68-year-old man who developed alteration in mental status, physical weakness and fatigue after nine cycles of nivolumab 3 mg/kg every two weeks.
Nivolumab-induced autoantibody negative limbic encephalitis in a patient with Hodgkin lymphoma.
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Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature.
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We report a case of nivolumab-induced delayed-onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach.
View Article and Find Full Text PDFNivolumab-induced Limbic Encephalitis with Anti-Hu Antibody in a Patient With Advanced Pleomorphic Carcinoma of the Lung.
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Hematology/Respiratory Medicine, Kanazawa University Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa, Japan.
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