AI Article Synopsis
- Crizotinib has shown effectiveness in treating non-small-cell lung cancer (NSCLC) with C-ros oncogene 1 rearrangement, but it may cause cardiac issues like QTc prolongation and bradycardia.
- A patient on a lower dose developed heart failure after initial cardiac side effects from crizotinib.
- Adjusting the dosage to 250 mg once daily eliminated heart-related problems and allowed for a sustained positive response to treatment.
Article Abstract
Crizotinib shows antitumor activity against C-ros oncogene 1-rearranged non-small-cell lung cancer (NSCLC). While corrected QT interval (QTc) prolongation and bradycardia are known as cardiac adverse effects, little is known about crizotinib-related heart failure. Our patient with C-ros oncogene 1-rearranged NSCLC on a reduced dose of crizotinib (200 mg twice daily) after initially experiencing bradycardia and QTc prolongation developed crizotinib-induced heart failure. With further dose reduction (250 mg once daily), there was no recurrence of any cardiac adverse effects, and the patient achieved a long-term response. Although crizotinib can cause heart failure, continuation of crizotinib at a low dose may be an effective treatment option.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908384 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.9157-21 | DOI Listing |
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