Self-supervised learning for multi-center magnetic resonance imaging harmonization without traveling phantoms.

With the progress of artificial intelligence (AI) in magnetic resonance imaging (MRI), large-scale multi-center MRI datasets have a great influence on diagnosis accuracy and model performance. However, multi-center images are highly variable due to the variety of scanners or scanning parameters in use, which has a negative effect on the generality of AI-based diagnosis models. To address this problem, we propose a self-supervised harmonization (SSH) method.Mapping the style of images between centers allows harmonization without traveling phantoms to be formalized as an unpaired image-to-image translation problem between two domains. The mapping is a two-stage transform, consisting of a modified cycle generative adversarial network (cycleGAN) for style transfer and a histogram matching module for structure fidelity. The proposed algorithm is demonstrated using female pelvic MRI images from two 3 T systems and compared with three state-of-the-art methods and one conventional method. In the absence of traveling phantoms, we evaluate harmonization from three perspectives: image fidelity, ability to remove inter-center differences, and influence on the downstream model.The improved image sharpness and structure fidelity are observed using the proposed harmonization pipeline. It largely decreases the number of features with a significant difference between two systems (from 64 to 45, lower than dualGAN: 57, cycleGAN: 59, ComBat: 64, and CLAHE: 54). In the downstream cervical cancer classification, it yields an area under the receiver operating characteristic curve of 0.894 (higher than dualGAN: 0.828, cycleGAN: 0.812, ComBat: 0.685, and CLAHE: 0.770).Our SSH method yields superior generality of downstream cervical cancer classification models by significantly decreasing the difference in radiomics features, and it achieves greater image fidelity.