Considerable confusion and uncertainty persist on the cultural and chronological contexts of Holocene microlithic assemblages reported from South Asia. The paucity of securely dated sites with microlithic remains has compounded the confusion. Evidence from sites securely attributed to the Mesolithic based on a holistic approach (including direct evidence of plant and animal exploitation strategies) is needed to provide a better understanding of Mesolithic lithic tool-kits. This study uses morphometric and statistical methods to assess the nature of the Holocene hunter-gatherer microlithic tools-kit from a radiometrically secured chronological context at Vaharvo Timbo, a recently excavated Mesolithic site in North Gujarat (India). The assemblage is further compared with the nearby contemporary site of Loteshwar to highlight similarities and differences within hunter-gatherer lithic assemblages, understanding which can provide detailed information about subsistence strategies as well as patterns of settlement and mobility. The results show general standardisation between these two sites regarding raw materials and manufacturing technique but variation in the relative abundance of tool types between these two sites, despite their close proximity, indicating diverse strategies of resource exploitation by the Holocene hunter-gatherer groups in western India.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216571 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267654 | PLOS |
Int J Equity Health
January 2025
Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Background: Predicting burn-related mortality is vital for family counseling, triage, and resource allocation. Several of the burn-specific mortality prediction scores have been developed, including the Abbreviated Burn Severity Index (ABSI) in 1982. However, these scores are not tested for accuracy to support contemporary estimates of the global burden of burn injury.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
All India Institute of Medical Sciences, New Delhi, India.
Background: Recent research on Alzheimer's disease (AD) has highlighted that the oxidative damage is the earliest event of disease. These oxidative modifications are closely associated with inflammatory molecules. It is necessary to explore these two pathways with AD pathophysiology and targeted for therapeutic intervention.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
All India Institute of Medical Sciences, AIIMS, New Delhi, Delhi, India.
Background: Alzheimer's disease (AD) is a progressive brain disorder which leads to gradual decline in memory, thinking, behaviour and social skills. The current scenario for drug development is based on neuro-inflammation and oxidative stress. Amyloid-β (Aβ) deposition, a major hallmark of the disease activates microglia leading to neuro-inflammation and neuro-degeneration induced by activation of COX-2 via NFkB p50 in glioblastoma cells.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
All India Institute of Medical Sciences, New Delhi, New Delhi, India.
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ plaques and neurofibrillary tangles, with chronic inflammation and synaptic dysfunction playing a significant contributor to disease progression and cognitive decline. Small extracellular vesicles (sEVs) are implicated in AD progression by facilitating the spread of pathological proteins and inflammatory cytokines. This study investigates the role of plasma-derived sEVs (PsEVs) in synaptic dysfunction and neuroinflammation and their association with amyloid-β and tau pathologies in AD progression.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: In low and middle-income countries like India, with limited treatment and support options, persons with dementia are primarily looked after by their families. Dementia's impact extends beyond the primary caregiver to the entire family. Involving and supporting family members in care can enhance the primary caregiver's well-being and improve the quality of care for the person with dementia.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!