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Visible-Light-Induced Oxyalkylation of 1,2,4-Triazine-3,5(2, 4)-diones with Ethers Oxidative Cross-Dehydrogenative Coupling. | LitMetric

Visible-Light-Induced Oxyalkylation of 1,2,4-Triazine-3,5(2, 4)-diones with Ethers Oxidative Cross-Dehydrogenative Coupling.

J Org Chem

School of Chemical Engineering and Technology, Hebei Provincial Key Lab of Green Chemical Technology & High Efficient Energy Saving, Tianjin Key Laboratory of Chemical Process Safety, Hebei University of Technology, Tianjin 300130, P. R. China.

Published: July 2022

AI Article Synopsis

Article Abstract

An efficient and convenient method to synthesize 6-oxyalkylated 1,2,4-triazine-3,5(2, 4)-diones has been developed visible-light-induced cross-dehydrogenative coupling reaction between 1,2,4-triazine-3,5(2, 4)-diones and ethers with a wide range of functional group tolerance. The present transformation employs the cheap and low-toxic 2--butylanthraquinone as a metal-free photocatalyst and air as a green oxidant at room temperature. Moreover, this reaction can also be driven by sunlight as a clean energy resource. The synthetic utility of this method is further demonstrated by gram-scale reaction and application in the preparation of key intermediates of bioactive molecules.

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Source
http://dx.doi.org/10.1021/acs.joc.2c00669DOI Listing

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