AI Article Synopsis
- - A 77-year-old woman developed cholangitis after receiving atezolizumab and nab-paclitaxel for breast cancer, presenting symptoms like fever and abdominal pain during her treatment.
- - Imaging revealed bile duct abnormalities, and a biopsy showed a high presence of CD8 T cells, leading to the diagnosis of atezolizumab-induced cholangitis.
- - After stopping the drug, the patient quickly recovered, with liver enzymes normalizing and symptoms resolving within 21 days, emphasizing the need to consider cholangitis in patients on immune checkpoint inhibitors.
Article Abstract
Cholangitis has been reported as an immune-related adverse event, although it rarely occurs. Here we report a case of cholangitis due to atezolizumab in a 77-year-old woman who had been treated with atezolizumab and nab-paclitaxel for breast cancer and lung metastasis. On the seventh cycle, she presented with fever and epigastric pain, and computed tomography and endoscopic ultrasound showed slight wall thickening of the common bile duct, and transpapillary bile duct biopsy was performed. Pathologically, CD8 T cells predominant infiltration was detected in the subepithelium of the bile duct, resulting in the diagnosis of atezolizumab-related cholangitis. The patient's symptoms were resolved immediately after discontinuing atezolizumab. Hepatobiliary enzymes returned to normal 21 days after onset, and bile duct wall thickening disappeared. Cholangitis should be included as the differential diagnosis of liver dysfunction in patients receiving immune checkpoint inhibitors.
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| http://dx.doi.org/10.1007/s12328-022-01651-3 | DOI Listing |
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