AI Article Synopsis
- The study assesses uterine artery embolization (UAE) as a treatment for symptomatic uterine fibroids, focusing on quality of life changes in patients after treatment.
- It analyzed data from 245 patients and found a 75.8% clinical success rate after nearly 10 years, with significant improvements in patient-reported outcomes.
- Results indicate that patients with smaller fibroids benefit more from UAE, experiencing better symptomatic relief compared to those with larger fibroids, who also faced a higher likelihood of needing further treatment.
Article Abstract
Background: The purpose of this study is to evaluate uterine artery embolization (UAE) for the management of symptomatic uterine leiomyomas regarding changes in quality of life after treatment in a large patient collective. This study retrospectively analyzed prospectively acquired standardized questionnaires of patients treated with UAE. Clinical success was evaluated before and after embolization. Patients were stratified into short- (≤ 7 months) and long-term (> 7 months) follow-up groups depending on the time of completion of the post-interventional questionnaire. Uterine leiomyomas were furthermore divided into small (< 10 cm) and large (≥ 10 cm) tumors based on the diameter of the dominant fibroid.
Results: A total of 245 patients were included into the final data analysis. The Kaplan-Meier analysis showed a cumulative clinical success rate of 75.8% after 70 months until the end of follow-up (9.9 years). All questionnaire subscales showed a highly significant clinical improvement from baseline to short- and long-term follow-up (p < 0.001). Patients with small fibroids showed a significantly better response to UAE in multiple subcategories of the questionnaire than patients with fibroids ≥ 10 cm who had a twofold higher probability of re-intervention in the Cox-regression model.
Conclusions: UAE is an effective treatment method for symptomatic fibroids that leads to quick relief of fibroid-related symptoms with marked improvement of quality of life and is associated with a low risk for re-interventions. Patients with small fibroids tend to show a better response to UAE compared to patients with large fibroids. Trial registration Charité institutional review board, EA4/167/20. Registered 27 November 2020-Retrospectively registered. https://ethikkommission.charite.de/.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213618 | PMC |
| http://dx.doi.org/10.1186/s13244-022-01244-1 | DOI Listing |
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