The successful synthesis of ruthenium oxide/reduced graphene oxide (RuO/rGO) heterostructures by one-pot hydrothermal method using graphene oxides and RuCl as precursors is reported. The heterostructures had high peroxidase-like (POD-like) activities, which catalyzes the oxidation of classical peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of HO to create a blue colored reaction product. The catalytic activity was significantly enhanced by the synergistic effect between RuO nanoparticles and rGO. RuO/rGO had a low K of 0.068 mM and a high v of 1.228 × 10 M·s towards TMB in the TMB-HO catalytic oxidation system. In addition, the POD-like activity originating from the electron transfer mechanism was confirmed by cytochrome C (Cyt C) oxidation experiment. A colorimetric method based on RuO/rGO heterostructures was developed with good sensitivity and selectivity for glucose detection with a limit of detection of 3.34 μM and a linear range of 0-1500 μM. The RuO/rGO heterostructures have potential applications in the biomedical areas, such as biosensor and diagnostics.
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| http://dx.doi.org/10.1007/s00604-022-05319-0 | DOI Listing |
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