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| http://dx.doi.org/10.1111/tct.13510 | DOI Listing |
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Motor abilities and cognitive performance in Latinos with autosomal dominant Alzheimer's disease.
J Prev Alzheimers Dis
January 2025
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center at the Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Background: Declining motor abilities might be a noninvasive biomarker for Alzheimer's disease (AD). Studying motor ability and AD progression in younger Latinos with autosomal dominant Alzheimer's disease (ADAD) can provide insights into the interplay between motor ability and cognition in individuals with minimal confounding from age-normative changes and comorbid medical conditions.
Objectives: This study aimed to (1) examine motor abilities as a function of years to dementia diagnosis and (2) examine associations between motor ability and cognitive performance.
Cognitive Predictors of Perception and Adaption to Dysarthric Speech in Older Adults.
J Speech Lang Hear Res
January 2025
Department of Communicative Disorders and Deaf Education, Utah State University, Logan.
Purpose: In effortful listening conditions, speech perception and adaptation abilities are constrained by aging and often linked to age-related hearing loss and cognitive decline. Given that older adults are frequent communication partners of individuals with dysarthria, the current study examines cognitive-linguistic and hearing predictors of dysarthric speech perception and adaptation in older listeners.
Method: Fifty-eight older adult listeners (aged 55-80 years) completed a battery of hearing and cognitive tasks administered via the National Institutes of Health Toolbox.
E2-Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells.
Nat Chem Biol
January 2025
State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.
The E2 ubiquitin (Ub)-conjugating enzyme primarily determines Ub conjugation as Ub-isopeptide (lysine), Ub-oxyester (serine/threonine) or Ub-thioester (cysteine). However, E2-specific Ub conjugation profiles within cells remain elusive. Here we developed the fusion E2-Ub-R74G profiling (FUSEP) strategy to access E2-specific Ub conjugation profiles in cells with amino acid resolution.
View Article and Find Full Text PDFDevelopment of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells.
Nat Commun
January 2025
School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Dissection of the physiological interactomes of histone post-translational modifications (hPTMs) is crucial for understanding epigenetic regulatory pathways. Peptide- or protein-based histone photoaffinity tools expanded the ability to probe the epigenetic interactome, but in situ profiling in native cells remains challenging. Here, we develop a nucleus-targeting histone-tail-based photoaffinity probe capable of profiling the hPTM-mediated interactomes in native cells, by integrating cell-permeable and nuclear localization peptide modules into an hPTM peptide equipped with a photoreactive moiety.
View Article and Find Full Text PDFFacial Emotion Recognition Ability in Individuals with Remitted Schizophrenia in Comparison to Healthy Population: A Cross-Sectional Study.
Indian J Psychol Med
January 2025
Dept. of Psychiatry, VMMC and Safdarjung Hospital, New Delhi, India.
Background: Facial emotion recognition is one of the significant domains of social cognition that underlie social interactions. These deficits can influence the functional outcome in individuals with schizophrenia by impairing judgment toward others and reducing their capability to function. We aimed to assess the facial emotion recognition deficits in individuals with schizophrenia in comparison to healthy individuals and find their association with clinical and demographic profiles.
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