AI Article Synopsis
- - The study investigates the connection between tumor thickness and aggressive growth patterns in basal cell carcinoma (BCC) by reviewing 85 primary BCC cases.
- - Out of the tumors analyzed, 27% displayed an aggressive growth pattern, which correlated with a higher average tumor thickness compared to non-aggressive tumors.
- - The findings suggest that measuring tumor thickness could be a useful method for assessing the potential risk level of BCC.
Article Abstract
Background: The significance of tumor thickness is not clear in the prognosis of basal cell carcinoma. We aimed to identify the relationship between the tumor thickness and aggressive histopathological growth pattern in BCC.
Methods: We retrospectively reviewed 85 primary BCCs of 82 patients. A total of 78 (91.7%) tumor slides were available for review, 7 (8.2%) missing slides in archive could not to be re-evaluated. We recorded the histological subtype, ulceration, perineural invasion, and the tumor thickness. Tumors with infiltrative, micronodular, morpheaform and basosquamous features were classified as having an aggressive growth pattern.
Results: The aggressive growth pattern was determined in 21 (26.9%) tumors with a mean tumor thickness of 2.19 ± 0.71 mm (range, 0.9-3.40). The non-aggressive growth pattern was detected in 57 (73%) tumors and the mean tumor thickness was 1.76 ± 0.87 mm (range 0.50-4.40 mm). There was a statistically significant difference in the mean tumor thickness between the tumors with aggressive growth pattern and non-aggressive growth pattern (p = 0.033).
Conclusion: Tumor thickness might have positive correlation with aggressive histological pattern. Measuring and reporting tumor thickness may be a more practical way to determine the pathological risk for BCC.
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| http://dx.doi.org/10.1111/jocd.14475 | DOI Listing |
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