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General infertility workup in times of high assisted reproductive technology efficacy. | LitMetric

General infertility workup in times of high assisted reproductive technology efficacy.

Fertil Steril

Department of Obstetrics, Gynecology and Reproductive Medicine, Hospital Foch-Faculté de Medicine Paris Ouest (UVSQ), Suresnes, France.

Published: July 2022

AI Article Synopsis

  • The assessment of oocyte quality, quantity, and hormonal profiles is crucial for diagnosing infertility in couples, using various clinical and functional biomarkers to evaluate ovarian function.
  • Recent advancements in genetic testing have introduced new markers that help predict how women will respond to ovarian stimulation, leading to safer and more effective assisted reproductive techniques.
  • This review focuses on current and emerging strategies for assessing ovarian function and endocrine disorders in women attempting to conceive, including the incorporation of genetic biomarkers and expanded carrier screening in infertility evaluations.

Article Abstract

The assessments of oocyte quality and quantity and endocrine profile have traditionally been the cornerstone of the general workup of couples with infertility. Over the years, several clinical, hormonal, and functional biomarkers have been adopted to assess ovarian function and identify endocrine disorders before assisted reproductive technology. Furthermore, the genetic workup of patients has drastically changed, introducing novel markers. This not only allowed the prediction of response to ovarian stimulation but also contributed toward the development of a safer and more efficient management of women undergoing assisted reproductive technology. The scope of this review is to provide an overview of the current and novel strategies adopted for the assessment of ovarian function and ovulatory and endocrine disorders in women planning to conceive. Furthermore, it aims to provide an insight in the role of novel genetic biomarkers and use of expanded carrier screening as part of preliminary workup of women with infertility.

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Source
http://dx.doi.org/10.1016/j.fertnstert.2022.05.019DOI Listing

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