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Integrated Network Analysis of Symptom Clusters Across Monkeypox Epidemics From 1970 to 2023: Systematic Review and Meta-Analysis.

JMIR Public Health Surveill

February 2024

Key Laboratory of Molecular Biology for Infectious Diseases, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The worldwide spread of monkeypox (mpox) has witnessed a significant increase, particularly in nonendemic countries.

Objective: We aimed to investigate the changing clinical symptoms associated with mpox from 1970 to 2023 and explore their interrelations.

Methods: In this systematic review and meta-analysis, 3 electronic databases were searched for English peer-reviewed studies conducted from January 1970 to April 2023 that reported any symptoms among confirmed mpox cases.

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Otolaryngologic manifestations among MPOX patients: A systematic review and meta-analysis.

Am J Otolaryngol

December 2023

Department of Otolaryngology-Head & Neck Surgery, Columbia University Irving Medical Center, NewYork-Presbyterian Hospital, NY, New York, United States of America. Electronic address:

Purpose: MPOX has numerous otolaryngologic presentations that have been recognized as clinically important, especially with the onset of the 2022 outbreak. However, how these features vary across region and outbreak have yet to be elucidated or supported by meta-analysis. The objective of this study is to identify the otolaryngologic manifestations of MPOX across previous and current outbreaks and among endemic and non-endemic regions.

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Article Synopsis
  • - Monkeypox (mpox) is a viral infection that can spread through close contact with respiratory secretions and lesions from infected individuals, leading to various symptoms, including skin rashes and fever.
  • - A study conducted in Madrid involved analyzing 11 male patients (average age 32) with complications from mpox, noting issues like pharyngitis, penile edema, and genital ulcers.
  • - A multidisciplinary care team, including specialists from various fields, was established to enhance diagnosis and treatment for complicated mpox cases, resulting in improved patient management and successful outcomes without any life-threatening situations.
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Background: The monkeypox outbreak in 2022 caused concern in the public. Infected patients usually present prodromal symptoms, such as lesions on their skin and mucous membranes, including the oral cavity. The current study aims to review the most common oral/perioral manifestations reported to date.

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