Increased Prevalence of Minocycline-Resistant with (M) by Tetracycline Use for Acne Treatment.

, a major skin bacterium, can cause opportunistic infections. Use of antimicrobial agents against for acne treatment becomes a risk factor for emergence of antimicrobial-resistant skin bacteria. In this study, the impact of antimicrobial treatment of acne vulgaris on antimicrobial resistance was assessed. A total of 344 strains isolated from patients with acne vulgaris who visited hospital (165 strains) and dermatological clinics (179 strains), respectively, were analyzed. Except for doxycycline, the resistance rates were higher in strains isolated from patients who had used antimicrobials for acne treatment than in those isolated from patients who had not used antimicrobials. The prevalence rates of strains with (C) from patients who used macrolides and clindamycin (hospital, 78.0%; clinics, 61.3%) and those of strains with (M) from patients who used tetracyclines (hospital, 27.5%; clinics, 42.4%) were significantly higher than those of strains from patients who did not use antimicrobials ( < 0.05). All strains with (A) (8/8) and 91.7% strains with (C) (156/170) showed high-level resistance to macrolides and clindamycin (MIC ≥256 μg/mL). Furthermore, almost all strains with (M) showed resistance to minocycline. Our results showed that the use of antimicrobials for acne treatment may lead to an increased prevalence of antimicrobial-resistant . In particular, the emergence of minocycline-resistant strains with (M) owing to the use of tetracyclines (doxycycline and minocycline) is a critical issue. Appropriate antimicrobial use for acne treatment may be an important strategy to prevent the emergence of antimicrobial-resistant skin bacteria.