Sleep disturbances and short sleep duration are common in pregnancy and might contribute to the development of hyperglycemia. Therefore, we evaluated the association of sleep disturbances and gestational diabetes (GDM) in a cohort of women.We collected data of 386 women consecutively screened for GDM in 2019 by 75 gr OGTT, according with IDPSG criteria. Pittsburgh Sleep Quality Index (PSQI) questionnaire was used to assess self-reported poor sleep quality (PSQI score >5) and short nocturnal sleep duration (<6 h).Of 386 women, 148 (38.3%) had poor sleep quality and 87 (22.5%) short sleep duration. GDM prevalence was 26.9%. There was no difference in GDM prevalence between women with poor or good sleep quality (26% 28%; n.s.), while GDM was more frequent in women with short sleep duration (35.6% vs. 24.4%; = 0.038). On univariate logistic regression analysis, short sleep duration (OR 1.71; 95%CI: 1.03-2.86; = 0.039), previous GDM (OR 3.52; 95%CI: 1.83-6.76; < 0.0001), family history of diabetes (OR 1.96; 95%CI: 1.21-3.91; = 0.007), pre-pregnancy overweight (OR 1.85; 95%CI: 1.06-3.23; = 0.031) or obesity (OR 2.56; 95%CI: 1.40-4.70; = 0.002) were associated to GDM. However, after adjustment for confounders, short sleep duration did not persist as an independent risk factor for GDM (OR: 1.55; 95%CI: 0.91-2.65; ns).Sleep disturbances are relative common among pregnant women. Although GDM seems more common among women with short sleep duration, this sleep disturbance does not seem to be an independent risk factor for GDM in women at high risk.
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http://dx.doi.org/10.1080/09513590.2022.2089105 | DOI Listing |
PLoS One
January 2025
Department of Disease Control and Environmental Health, School of Public Health, Makerere University, Kampala, Uganda.
Background: Psychoactive substance use in adults and second-hand smoke (SHS) exposure among children are leading contributors to sleeping problems. Despite this, there is limited data on how these exposures influence sleep patterns in informal settings. Our study assessed the associations between substance use, SHS exposure and sleep disturbances among adults and children in an urban informal settlement in Uganda.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cornell University, Ithaca, NY, USA.
Background: Alzheimer's disease (AD) manifests with early spatial memory impairment and is linked to the degeneration of hippocampal circuits. Hippocampal sharp wave ripples (SWRs) are high-frequency population-burst events that coordinate the reactivation of neural assemblies (groups of neurons that become correlated in their firing patterns during learning) in post-learning sleep, which is the neural basis of memory consolidation. SWRs are reduced in the APP/PS1 mouse model of AD-like pathology.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Ahmadu Bello University, Zaria, Kaduna, Nigeria.
Background: Sleep deprivation leads to an increase in oxidative stress and activation of inflammatory response and both could increase the production and accumulation of toxic beta-amyloid in the hippocampus which is considered one of the molecular drivers of Alzheimer's pathogenesis and progression. Despite these findings, obtaining sleep is still challenging in our modern society that values work around the clock. Omega-3 fatty acids represents an active biological agent with vital antioxidant and anti-inflammatory activities that could protect memory in the face of insufficient sleep.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Kentucky, Lexington, KY, USA.
Background: Alzheimer's disease is defined by the pathological aggregation of amyloid-beta and hyperphosphorylated tau. AD patients often exhibit other symptoms like metabolic and sleep dysfunction. Currently, it is unclear if impairments are a cause or consequence of Aβ or tau aggregation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
NYU Grossman School of Medicine, New York, NY, USA.
Background: We examined racial differences between measures of limbic white matter tracts and objective sleep parameters in cognitively unimpaired older-adults.
Method: This cross-sectional study included 170 community-dwelling cognitively unimpaired older-adults (mean±SD: age = 67.2±5.
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