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Efficacy of intralesional pentoxifylline versus intralesional steroid versus intralesional vitamin D in treatment of keloid.
Arch Dermatol Res
January 2025
Medicine and General Surgery, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Several treatment modalities have been used for the treatment of keloid scarring but the optimal treatment has not yet been identified. Corticosteroids reduce excessive scarring by reducing collagen synthesis. Vitamin D can curb inflammation by inhibiting the activation and migration of leukocytes.
View Article and Find Full Text PDFSalidroside Prevents Keloid Fibroblast Aggressive Progression by Upregulating miR-26a-5p to Inhibit JAG1.
Cell Biochem Biophys
January 2025
Department of Radiology, CR&WISCO GENERAL HOSPITAL, Wuhan, 430000, Hubei, China.
Salidroside, a natural herb, exerts considerable anti-tumor effects in various human cancers. Evidence unveils that Salidroside mediates gene expression to affect cancer progression. Our work intended to uncover the molecular mechanism of Salidroside functional role in keloid.
View Article and Find Full Text PDFSurgical Excision and Radiotherapy for Giant Keloids in Auricula: A Case Report.
Int Med Case Rep J
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Keloids are characterized by excessive growth of fibrous tissue resulting from abnormal wound-healing processes. They may lead to functional impairments, aesthetic deformities, pruritus, and a decreased quality of life. Various therapies, including intralesional corticosteroid injections, cryotherapy, laser therapy, surgical excision, and radiotherapy, have been used to manage keloids, but the recurrence rates remain high.
View Article and Find Full Text PDFMicrobial analyses of infectious keloids on the anterior chest-a case-control study.
Arch Dermatol Res
January 2025
Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Some studies have confirmed that pathogens can cause infection through bacterial cultures on the surface of infectious keloids. However, further exploration of the comparison between infectious and non-infectious keloids and the bacterial flora of infectious foci is lacking. To investigate the differential flora of purulent secretions on the surface of infectious keloids compared to non-infectious keloids and to determine the microbial composition within the infectious foci.
View Article and Find Full Text PDFVascular Basement Membrane Fragmentation in Keloids and the Expression of Key Basement Membrane Component Genes.
Plast Reconstr Surg Glob Open
December 2024
From the Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo, Japan.
Background: Keloids are growing scars that arise from injury to the reticular dermis and subsequent chronic local inflammation. The latter may be promoted by vascular hyperpermeability, which permits the ingress of chronic inflammatory cells/factors. Cutaneous capillaries consist of endothelial cells that generate, and are anchored by, a vascular basement membrane (VBM).
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