Serum Vitamin D Insufficiency in Hospitalized Full-Term Neonates at a Tertiary Hospital in Eastern China.

Objective: This study explored the status of serum vitamin D in hospitalized full-term neonates at a tertiary hospital in eastern China.

Methods: A prospective study was conducted among 471 hospitalized full-term neonates at the Children's Hospital of Soochow University between January 1 and June 20, 2020. Perinatal clinical data, serum 25-hydroxyvitamin D (25(OH)D), laboratory examinations, serum calcium levels, and immune function were obtained and analyzed. We explored and analyzed the risk factors for vitamin D insufficiency or deficiency, and we also attempted to determine correlations between vitamin D and its influence on immunity.

Results: The mean serum 25(OH)D was 33.65±6.07ng/ml.The prevalence of vitamin D insufficiency was 28.24%,vitamin D sufficiency was 71.76%, there was no vitamin D deficiency. The serum 25-(OH)D in singleton neonate was higher than twins or multiple infants ( = -10.918, = 0.000). The serum 25-(OH)D were higher in neonates who born in spring and summer than in winter (H = 13.443, = 0.001). The serum 25-(OH)D in appropriate for gestational age (AGA) and large for gestational age (LGA) neonates were higher than small for gestational age (SGA) (H = 7.686, = 0.021). The serum 25-(OH)D were higher in neonates whose mothers had no underlying diseases than those with certain immunological and infectious diseases (F = 12.417, = 0.000). The serum 25-(OH)D in neonates whose mothers had none or one perinatal complication were higher than those with two or more (F = 13.299, = 0.000). The neonates with eosinophils ≤5% or normal platelet counts or serum Ca ≥0.9 mmol/L have higher serum 25-(OH)D. Neonates born in winter were at risk for vitamin D insufficiency, and the incidence of infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia in the vitamin D insufficiency group were higher than sufficiency group ( < 0.05). The serum CD3+, CD3+CD4+, and IgA levels in vitamin D sufficiency neonates were significantly higher than those in insufficiency group ( < 0.05).

Conclusion: The prevalence of vitamin D insufficiency was 28.24%, and birth in winter was a risk factor for vitamin D insufficiency in hospitalized full-term neonates in Suzhou area. Neonates with infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia exhibited a high risk of vitamin D insufficiency. The serum CD3, CD3CD4, and IgA levels in neonates with vitamin D insufficiency were lower.