AI Article Synopsis
- - Deep brain stimulation (DBS), used for treating Parkinson's disease, can generate distinct EEG responses based on specific brain areas stimulated, as shown by different peaks in evoked potentials (P3 and P10) related to stimulation of the dorsolateral subthalamic nucleus and substantia nigra respectively.
- - The study aimed to explore whether the new multiple independent current control (MICC) technology could produce unique neurophysiological responses by precisely adjusting the electric field between DBS contacts.
- - Results indicated that varying the electric field location significantly affected the amplitudes of the P3 and P10 responses, suggesting that MICC could enhance the precision of DBS programming for individual patients.
Article Abstract
Background: Deep brain stimulation (DBS) is an effective neuromodulation therapy to treat people with medication-refractory Parkinson's disease (PD). However, the neural networks affected by DBS are not yet fully understood. Recent studies show that stimulating on different DBS-contacts using a single current source results in distinct EEG-based evoked potentials (EPs), with a peak at 3 ms (P3) associated with dorsolateral subthalamic nucleus stimulation and a peak at 10 ms associated with substantia nigra stimulation. Multiple independent current control (MICC) technology allows the center of the electric field to be moved in between two adjacent DBS-contacts, offering a potential advantage in spatial precision.
Objective: Determine if MICC precision targeting results in distinct neurophysiological responses recorded EEG.
Materials And Methods: We recorded cortical EPs in five hemispheres (four PD patients) using EEG whilst employing MICC to move the electric field from the most dorsal DBS-contact to the most ventral in 15 incremental steps.
Results: The center of the electric field location had a significant effect on both the P3 and P10 amplitude in all hemispheres where a peak was detected (P3, detected in 4 of 5 hemispheres, < 0.0001; P10, detected in 5 of 5 hemispheres, < 0.0001). analysis indicated furthermore that MICC technology can significantly refine the resolution of steering.
Conclusion: Using MICC to incrementally move the center of the electric field to locations between adjacent DBS-contacts resulted in significantly different neurophysiological responses that may allow further precision of the programming of individual patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203070 | PMC |
| http://dx.doi.org/10.3389/fnhum.2022.896435 | DOI Listing |
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