Hydrogen sulfide (HS) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that HS plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in HS biogenesis has been reported in a variety of vascular diseases and HS supplementation exerts effects of vasodilation. Accumulating evidence has shown vascular potassium channels activation is involved in HS-induced vasodilation. This review aimed to summarize and discuss the role of HS in the regulation of vascular tone, especially by interaction with different vascular potassium channels and the underlying mechanisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198332 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.911704 | DOI Listing |
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