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Nematocidal activity of chitosan nanoparticles conjugated with albendazole against the enteral and parenteral phases of trichinosis in experimentally infected mice.
J Parasit Dis
March 2024
Medical Parasitology Department, Faculty of Medicine, Kasr Al-Ainy, Cairo University, Cairo, Egypt.
Trichinosis is a serious parasitic zoonotic disease caused mainly by The used drugs for treatment of trichinosis showed limited bioavailability and high degree of resistance. Moreover, they have a very poor effect in treatment of encysted larvae. Therefore, there is a need for development of new agents which help in improving the bioavailability of the used drugs and enable them to reach different tissues.
View Article and Find Full Text PDFNanocurcumin: A Promising Therapeutic Candidate for Experimental Trichinellosis.
Microsc Microanal
April 2024
Department of Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71526, Egypt.
In our pursuit of an alternative drug against Trichinella spiralis, we assessed the effectiveness of nanocurcumin in alleviating pathogenesis, parasitological factors, MMP-9 levels, and its expression in the enteral and parenteral phases of infection. The nanocurcumin particles, with a spherical shape and a size of 100 ± 20 nm, were used in the study. Eighty mice were divided into four groups: the control group, the untreated infected group, the nanocurcumin-treated group, and the albendazole-treated group.
View Article and Find Full Text PDFThe impact of β-glucan on the therapeutic outcome of experimental Trichinella spiralis infection.
Parasitol Res
December 2023
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Trichinellosis is a cosmopolitan zoonosis that is caused mainly by Trichinella spiralis infection. The human disease ranges from mild to severe and fatality may occur. The treatment of trichinellosis still presents a challenge for physicians.
View Article and Find Full Text PDFAntinematodic effect of Enterococcus faecalis CECT7121 using Trichinella spiralis as a model of nematode infection in mice.
Exp Parasitol
October 2022
Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Facultad de Ciencias Veterinarias, Campus Universitario, B7000, Tandil, Buenos Aires, Argentina.
Nematode infections affect a significant percentage of the human population worldwide, especially in developing countries. There are a small number of drugs available to treat these infections, with variable outcomes. Therefore, the potential use of probiotics to help control parasitic infections has emerged as a suitable option.
View Article and Find Full Text PDFEgyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight.
J Helminthol
July 2022
Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Trichinosis is a serious zoonotic disease that causes human morbidity and mortality. New effective natural remedies with minimal side effects that are well tolerated are needed to treat both enteral and parenteral trichinosis. This study evaluated the efficacy of selenium (Se), Se nanoparticles (SeNPs) and Egyptian propolis compared with albendazole as antiparasitic, anti-inflammatory and anti-angiogenic agents for treating murine trichinosis.
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