AI Article Synopsis
- * Findings reveal that ADAM17 is highly expressed in various tissues, particularly in respiratory cells, and that higher levels are associated with worse prognosis in cancer patients, alongside significant links to immune cell infiltration.
- * The research also identifies eight small molecules that target ADAM17, suggesting potential therapeutic approaches for cancer patients with COVID-19 and highlighting ADAM17's relevance in treatment strategies.
Article Abstract
SARS-Cov-2 caused the COVID-19 pandemic worldwide. ADAM17 functions as a disintegrin and transmembrane metalloproteinase domain protein involved in the regulation of SARS-CoV-2 receptor ACE2. However, its impact on cancer patients infected with COVID-19 and its correlation with immune cell infiltration is unclear. This study compared ADAM17 expression between normal and tumor tissues based on GEPIA. The correlations between ADAM17 expression and immune cell infiltration and immunomodulators were investigated. Besides, treated drugs for targeting ADAM17 were searched in the TISDB database. We found that ADAM17 was highly conserved in many species and was mainly expressed in lung, brain, female tissues, bone marrow and lymphoid tissues. It was also highly expressed in respiratory epithelial cells of rhinitis and bronchus. ADAM17 expression in tumors was higher than that in several paired normal tissues and was negatively correlated with the prognosis of patients with malignant tumors. Interestingly, ADAM17 expression significantly correlated with immunomodulators and immune cell infiltration in normal and tumor tissues. Moreover, eight small molecules targeting ADAM17 only demonstrate therapeutic significance. These findings imply important implications for ADAM17 in cancer patients infected with COVID-19 and provide new clues for development strategy of anti-COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203860 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.923516 | DOI Listing |
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