AI Article Synopsis
- The study aimed to evaluate antibody responses to the SARS-CoV-2 virus after receiving the Covishield vaccine over a period of 6 months.
- Over 51% of participants were already seropositive before vaccination, and nearly all became seropositive after the second dose, with antibody levels peaking one month post-vaccination.
- Antibody levels decreased significantly by 6 months, particularly in older participants, indicating the need for potential booster doses to maintain immunity.
Article Abstract
Objective: To evaluate severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific antibody responses after Covishield vaccination for 6 months after vaccination.
Design: SARS-CoV-2-specific antibody responses were assessed by enzyme-linked immunosorbent assay of the recombinant receptor-binding domain of SARS-CoV-2 in 381 adults given the Covishield vaccine at baseline (=119), 1 month (=126) and 2 months (=75) after the first dose, 1 month after the second dose (=161), and monthly for 3 additional months.
Results: Over 51% of participants were seropositive at baseline (before vaccination with Covishield), and almost all participants (159/161) became seropositive 1 month after the second dose. Antibody levels peaked 1 month after receipt of the second dose of vaccine, and decreased by 4 months after the first dose; the lowest responses were found 6 months after the first dose, although antibody responses and responder frequencies remained significantly higher compared with baseline (<0.0001). Compared with younger participants, older participants had lower antibody responses 6 months after the first dose of vaccine (<0.05). Participants who had previous SARS-CoV-2 infection showed robust higher antibody responses after vaccination.
Conclusions: These findings help to elucidate the longevity of vaccine-specific antibody responses following vaccination with Covishield, and provide information relevant to the planning of booster doses after the initial two doses of vaccine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050186 | PMC |
| http://dx.doi.org/10.1016/j.ijregi.2022.04.006 | DOI Listing |
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