AI Article Synopsis
- - Ferroptosis is a type of cell death caused by iron and involves lipid peroxidation, with implications in various conditions like tumors and neurological diseases.
- - The article focuses on how ferroptosis affects chronic liver diseases, covering mechanisms related to System Xc-, iron and lipid metabolism, and GPX4-independent pathways.
- - It discusses recent research on ferroptosis in liver diseases like alcoholic and non-alcoholic fatty liver disease, while also addressing current challenges in understanding this process to find new treatment targets.
Article Abstract
Ferroptosis, an iron-dependent non-apoptotic cell death characterized by lipid peroxidation, is a cell death pathway discovered in recent years. Ferroptosis plays an important role in tumors, ischemia-reperfusion injury, neurological diseases, blood diseases, etc. Recent studies have shown the importance of ferroptosis in chronic liver disease. This article summarizes the pathological mechanisms of ferroptosis involved in System Xc-, iron metabolism, lipid metabolism, and some GPX4-independent pathways, and the latest research on ferroptosis in chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, liver fibrosis, hepatocellular carcinoma. In addition, the current bottleneck issues that restrict the research on ferroptosis are proposed to provide ideas and strategies for exploring new therapeutic targets for chronic liver diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205467 | PMC |
| http://dx.doi.org/10.3389/fmolb.2022.928321 | DOI Listing |
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