Transport planning and policy is increasingly being called to action in ways that differ from practices of yesteryear. Varied segments of society are increasingly looking to city streets-the workhorse of a city's transport system-as places to enact change. Namely, to change their character away from the type of streets pervasive in auto-oriented urban environments. Acutely experienced during the disruption of the COVID-19 pandemic, emergency response measures from many cities across the world abruptly altered the nature and purpose of street space. These "street experiments" fueled an opportunity, in part, to explore a transition to practices prioritizing forms of sustainable mobility such as walking and bicycling. This research inventories street-focused emergency response measures from the 55 largest cities in the US. We devise a rubric to systematically assess and locate characteristics of these measures that enable a transition. Results show that five "innovator" and several "early adopter" cities are using COVID conditions to test new forms of streets and in some cases, street networks. These cities excelled in conveying a vision for alternative future, articulating implementation pathways, leveraging political capacity, and circulating information. After six months, half of the cities continue their efforts, including only six which have expanded. The few showing continued strength demonstrate endeavors to evaluate the experiments, validate their feasibility, and embed the experiments into existing sustainability policy. These components, when leveraged together, could seed innovative break-throughs in how city streets are used, designed, and standardized. The paper establishes baseline evidence on which future research efforts can build and provides empirical evidence on early stages of the experimentation and transition processes of urban mobility systems.
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http://dx.doi.org/10.1016/j.tranpol.2021.01.015 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
Department of Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, Guangdong 510060, P. R. China.
The clinical application of tyrosine kinase inhibitors (TKIs) is rapidly growing and has emerged as a cornerstone in the treatment of both solid tumors and hematologic malignancies. However, resistance to TKI targets and disease progression remain inevitable. Nanocarrier-mediated delivery has emerged as a promising strategy to overcome the limitations of the TKI application.
View Article and Find Full Text PDFJ Med Internet Res
January 2025
Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, United Kingdom.
Background: The literature is equivocal as to whether the predicted negative mental health impact of the COVID-19 pandemic came to fruition. Some quantitative studies report increased emotional problems and depression; others report improved mental health and well-being. Qualitative explorations reveal heterogeneity, with themes ranging from feelings of loss to growth and development.
View Article and Find Full Text PDFShock
January 2025
Pharmacology, University of Vermont, Burlington, VT.
Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott Syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of TMEM16F in endothelial cells, however, is not well understood. We sought to test the hypothesis that endothelial TMEM16F contributes to hemostasis by measuring bleeding time and venous clotting in endothelial-specific knockout (ECKO) mice.
View Article and Find Full Text PDFAnn Rheum Dis
January 2025
Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
The increasing prevalence of autoimmune and immune-mediated diseases (AIMDs) underscores the need to understand environmental factors that contribute to their pathogenesis, with the microbiome emerging as a key player. Despite significant advancements in understanding how the microbiome influences physiological and inflammatory responses, translating these findings into clinical practice remains challenging. This viewpoint reviews the progress and obstacles in microbiome research related to AIMDs, examining molecular techniques that enhance our understanding of microbial contributions to disease.
View Article and Find Full Text PDFRes Nurs Health
January 2025
Nursing Department, Universitat Rovira i Virgili, Tarragona, Spain.
The patient activation measure (PAM), a recognized measure of how active patients are in their care, is one of the most extensively used, widely translated, and tested instruments worldwide in measuring patient activation. This study aimed to assess the psychometric properties and construct validity of the Italian version of the 13-item Patient Activation Measure (PAM13-I) among patients undergoing elective laparoscopic cholecystectomy. A multicenter study was conducted across 111 surgical units in Italy.
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