This paper proposes a two-level, data-driven, digital twin concept for the autonomous landing of aircraft, under some assumptions. It features a digital twin instance (DTI) for model predictive control (MPC); and an innovative, real-time, digital twin prototype for fluid-structure interaction and flight dynamics to inform it. The latter digital twin is based on the linearization about a pre-designed glideslope trajectory of a high-fidelity, viscous, nonlinear computational model for flight dynamics; and its projection onto a low-dimensional approximation subspace to achieve real-time performance, while maintaining accuracy. Its main purpose is to predict in real time, during flight, the state of an aircraft and the aerodynamic forces and moments acting on it. Unlike static lookup tables or regression-based surrogate models based on steady-state wind tunnel data, the aforementioned real-time digital twin prototype allows the DTI for MPC to be informed by a truly dynamic flight model, rather than a less accurate set of steady-state aerodynamic force and moment data points. The paper describes in detail the construction of the proposed two-level digital twin concept and its verification by numerical simulation. It also reports on its preliminary flight validation in autonomous mode for an off-the-shelf unmanned aerial vehicle instrumented at Stanford University. This article is part of the theme issue 'Data-driven prediction in dynamical systems'.
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http://dx.doi.org/10.1098/rsta.2021.0204 | DOI Listing |
Holographic light potentials generated by phase-modulating liquid-crystal spatial light modulators (SLMs) are widely used in quantum technology applications. Accurate calibration of the wavefront and intensity profile of the laser beam at the SLM display is key to the high fidelity of holographic potentials. Here, we present a new calibration technique that is faster than previous methods while maintaining the same level of accuracy.
View Article and Find Full Text PDFJ Appl Crystallogr
January 2024
NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
Neutron reflectometry (NR) is a powerful technique for interrogating the structure of thin films at interfaces. Because NR measurements are slow and instrument availability is limited, measurement efficiency is paramount. One approach to improving measurement efficiency is active learning (AL), in which the next measurement configurations are selected on the basis of information gained from the partial data collected so far.
View Article and Find Full Text PDFPerspect Clin Res
August 2024
Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Post-COVID-19, the emergence of newer technologies has taken center stage. One such technology is metaverse, which is an extension of existing technologies such as virtual reality (VR) and augmented reality (AR) that enables a fully immersive communication platform through the utilization of digital twins and avatars in a three-dimensional digital space. Literature review has shown that the adoption of such technologies in the field of clinical trials can help in improving the therapeutic outcomes in patients while having numerous other benefits.
View Article and Find Full Text PDFPrediction-powered inference (PPI) [1] and its subsequent development called PPI++ [2] provide a novel approach to standard statistical estimation leveraging machine learning systems to enhance unlabeled data with predictions. We use this paradigm in clinical trials. The predictions are provided by disease progression models, providing prognostic scores for all the participants as a function of baseline covariates.
View Article and Find Full Text PDFMed Image Anal
January 2025
School of Biomedical Engineering and Imaging Sciences, King's College London, UK. Electronic address:
Atrial fibrillation (AF), impacting nearly 50 million individuals globally, is a major contributor to ischaemic strokes, predominantly originating from the left atrial appendage (LAA). Current clinical scores like CHA₂DS₂-VASc, while useful, provide limited insight into the pro-thrombotic mechanisms of Virchow's triad-blood stasis, endothelial damage, and hypercoagulability. This study leverages biophysical computational modelling to deepen our understanding of thrombogenesis in AF patients.
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