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Objective: To compare two commercial formulations of alfaxalone for immersion anaesthesia in laboratory zebrafish.
Study Design: Prospective, blinded, randomized study.
Animals: A total of 20 adult Danio rerio (Tuebingen strain).
Methods: Zebrafish were divided into two groups of 10 (five female, five male) and placed in individual immersion baths containing 10 mg L of unpreserved alfaxalone (group 1) or preserved alfaxalone (group 2). Anaesthetists blinded to treatment used a composite score scale (CSS) (range 0-12) to assess fish every 30 seconds until induction of anaesthesia. Anaesthetic induction occurred when equilibrium and response to stimulus were lost. Fish were then placed in a clean water bath and scored every 60 seconds. Recovery from anaesthesia was defined as a CSS of ≤ 1. Time variables recorded were anaesthetic induction time (AIT), anaesthetic recovery time (ART) and total procedure time (TPT). Fish were observed for evidence of roupgross external pathology during the procedure. Following anaesthesia, four fish from each group were randomly chosen and euthanized for gill histopathology analysis immediately after recovery criteria were met. Data are presented as mean ± standard deviation. An independent t test was used to compare the difference in average anaesthetic time variables between groups (α = 0.05).
Results: There were no statistical differences between groups in reported variables. TPT, AIT and ART were 10.2 ± 1.2, 1.9 ± 0.9 and 8.3 ± 1.2 minutes for group 1 and 10.8 ± 2.9, 2.4 ± 1.2 and 8.4 ± 2.7 minutes for group 2. No gross external pathology was evident, and no fish died during the experimental period. Histopathology showed normal gill pathology and no difference between the groups.
Conclusions And Clinical Relevance: Immersion anaesthesia using 10 mg L of either formulation of alfaxalone resulted in anaesthesia of similar quality and duration.
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http://dx.doi.org/10.1016/j.vaa.2022.05.001 | DOI Listing |
BMC Anesthesiol
December 2024
Department of Anesthesiology, Ningbo No.2 Hospital, No.41, Northwest Street, Ningbo, 315010, P.R. China.
Background: Developing proficiency in ultrasound-guided nerve block (UGNB) demands an intricate understanding of cross-sectional anatomy as well as spatial reasoning, which is a big challenge for beginners. The aim of this pilot study was to evaluate the feasibility of virtual reality (VR)-facilitated anatomy education in the first performance of ultrasound-guided interscalene brachial plexus blockade among novice anesthesiologists. We carried out pilot testing of this hypothesis using a prospective, single blind, randomized controlled trial.
View Article and Find Full Text PDFTrials
December 2024
Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, USA.
Background: In an aging surgical patient population, preventing complications such as oversedation has taken increasing priority in perioperative care. Intraoperative use of virtual reality (VR) may decrease sedative requirements. We hypothesize that the use of immersive VR during total knee arthroplasty (TKA) will lead to decreased propofol requirements, improved patient-reported satisfaction, and reduced postoperative opioid requirements compared to active and usual care controls.
View Article and Find Full Text PDFHealthcare (Basel)
December 2024
Department of Nursing, Physiotherapy and Medicine, Faculty of Health Sciences, University of Almeria, 04120 Almeria, Spain.
Aims: This study assessed the effect of immersive virtual reality (IVR) on anxiety and intraoperative pain in adult patients undergoing dental extractions with local anesthesia.
Methods: In a single-blind, randomized clinical trial from September 2022 to December 2023 at a private dental clinic, 190 patients with dental anxiety were randomly assigned to either an IVR or a control group. Primary outcomes-dental anxiety and perioperative pain-were measured using the State-Trait Anxiety Inventory (STAI), Modified Dental Anxiety Scale (MDAS), and Visual Analogue Scale (VAS) before and after the procedure.
Diving Hyperb Med
December 2024
TAC Healthcare Group, Wellheads Industrial Estate, Aberdeen, United Kingdom.
This joint position statement (JPS) on immersion pulmonary oedema (IPO) and diving is the product of a workshop held at the 52nd Annual Scientific Meeting of the South Pacific Underwater Medicine Society (SPUMS) from 12-17 May 2024, and consultation with the United Kingdom Diving Medical Committee (UKDMC), three members of which attended the meeting. The JPS is a consensus of experts with relevant evidence cited where available. The statement reviews the nomenclature, pathophysiology, risk factors, clinical features, prehospital treatment, investigation of and the fitness for future compressed gas diving following an episode of IPO.
View Article and Find Full Text PDFInt J Surg Case Rep
November 2024
Department of Orthopedics and Traumatology, Université Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium. Electronic address:
Introduction: Dupuytren's contracture is a fibrotic disorder of the palmar fascia, leading to debilitating finger deformities. Traditional treatments, like open fasciectomy and collagenase injection, carry high risks of complications and recurrence. Ultrasound-guided techniques offer a potentially safer, minimally invasive alternative but are limited by the irregular skin surfaces and flexion deformities in Dupuytren's disease.
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