AI Article Synopsis
- - Five new sesquiterpenoids, named stellerasespenes A-E, along with four previously known compounds, were extracted from the roots of the plant Stellera chamaejasme.
- - The structures of these compounds were determined using detailed spectroscopic techniques, X-ray crystallography, and theoretical calculations.
- - Stellerasespene A demonstrated superior inhibition of nitric oxide production and reduced levels of the pro-inflammatory cytokine IL-1β in LPS-activated BV2 microglial cells, outperforming the control drug minocycline.
Article Abstract
Five undescribed sesquiterpenoids stellerasespenes A‒E and four reported congeners were isolated from the roots of Stellera chamaejasme. The structures were elucidated by comprehensive spectroscopic analyses together with X-ray single crystal diffraction and theoretical calculations. The structure of holosericin B was revised. All the isolated compounds were evaluated for NO production in murine microglial BV2 cells induced by LPS. Stellerasespene A showed better inhibitory activity than the positive control minocycline, inhibiting NO production and overexpression of pro-inflammatory cytokine IL-1β in LPS-activated BV2 cells.
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| http://dx.doi.org/10.1016/j.phytochem.2022.113275 | DOI Listing |
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