Statins are highly effective medications that reduce risk of atherosclerotic cardiovascular disease, but are very commonly discontinued by patients because of muscle symptoms. The risk factors for statin-associated muscle symptoms (SAMS) are not well understood, so in this study we examined the predictors of SAMS in a well-studied cohort of patients in the VITAL trial. We found that female sex and younger age (50-64 years) were significant, independent predictors of higher rates of SAMS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595449PMC
http://dx.doi.org/10.1016/j.ahj.2022.06.001DOI Listing

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