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The Use of Classic Psychedelics for Depressive and Anxiety-Spectrum Disorders: A Comprehensive Review.
J Clin Psychopharmacol
December 2024
From the Albert Einstein College of Medicine, Bronx, NY.
Following a decades-long decline in psychedelic research resulting from social, political, and legislative factors, there has been greatly renewed interest in these compounds' ability to treat psychiatric disorders. Classic psychedelics, encompassing both natural and synthetic psychoactive compounds, are characterized by their action as agonists or partial agonists of serotonin 5-hydroxytryptamine 2A receptors. In this comprehensive review, we summarize the latest clinical trials of classic psychedelics on depression and anxiety, attending to the patient demographics and methodology of each study.
View Article and Find Full Text PDFGlucocorticoid-Dependent Retinal Degeneration and Vision Impairment in Mice Susceptible to Prenatal Stress-Induced Behavioral Abnormalities.
Cell Mol Neurobiol
December 2024
Laboratory of Veterinary Biochemistry, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, South Korea.
Chronic exposure to prenatal stress can impair neurogenesis and lead to irreversible cognitive and neuropsychiatric abnormalities in offspring. The retina is part of the nervous system; however, the impacts of prenatal stress on retinal neurogenesis and visual function remain unclear. This study examined how elevated prenatal glucocorticoid levels differentially affect retinal development in the offspring of pregnant mice exposed to chronic unpredictable mild stress (CUMS).
View Article and Find Full Text PDFPolar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment.
J Vis Exp
December 2024
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences; Department of Psychology, University of Chinese Academy of Sciences;
The Acute Stress Disorder Scale (ASDS) is crucial for assessing acute stress disorder (ASD), especially in high-stress environments like Intensive Care Units (ICUs). Traditional methods struggle to interpret all 19 ASDS variables simultaneously. This study introduces a novel polar histogram visualization approach to enhance ASDS score analysis, focusing on elderly ICU caregivers.
View Article and Find Full Text PDFExamining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health.
Autism Res
December 2024
Research Group on Nutrition and Mental Health (NUTRISAM); Department of Psychology, Rovira i Virgili University, Tarragona, Spain.
Broader Autism Phenotype (BAP) traits may be present in parents of children on the autism spectrum. However, the prevalence and impact of these traits on parental mental health is poorly understood. We explore BAP traits and its relationship to mental health in 228 fathers and 261 mothers from a sample of 266 scholars from the EPINED study (Spain) grouped as follows: non-autism (N = 122), autism traits (N = 93: 38 subthreshold autism and 55 autism symptoms) and autism (N = 51).
View Article and Find Full Text PDFLoneliness in older persons with schizophrenia.
Int J Soc Psychiatry
December 2024
Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, New Zealand.
Background: In tandem with the rise in numbers of older adults in the general population, more people with schizophrenia (PwS) are also living longer. This vulnerable population has several trajectories of ageing driven by a number of social determinants of health, including the experience of loneliness and they may be more at risk of experiencing loneliness.
Aim: This study aimed to examine demographic, psychosocial and clinical variables and their relative contribution to the loneliness of older PwS (OPwS) in a large New Zealand community sample.
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