AI Article Synopsis
- * Researchers tested α-MSH in two different in vitro models of sarcoidosis and an in vivo mouse model, finding that it reduced inflammatory markers and immune cell counts associated with the disease.
- * The findings suggest that α-MSH could play a significant role in treating pulmonary sarcoidosis by targeting pathways involved in inflammation and immune response.
Article Abstract
Purpose: Alpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models.
Methods: We evaluated the anti-inflammatory effects of α-MSH on two different in vitro sarcoidosis models (lung-on-membrane model; LOMM and three-dimensional biochip pulmonary sarcoidosis model; 3D-BSGM) generated from NBECs and an in vivo sarcoidosis mouse model.
Results: Treatment with α-MSH decreased inflammatory cytokine levels and downregulated type I interferon pathway genes and related proteins in LOMM and 3D-BSGM models. Treatment with α-MSH also significantly decreased macrophages and cytotoxic T-cells counts in a sarcoidosis mice model.
Conclusion: Our results confirm the direct role of type I IFNs in the pathogenesis of sarcoid lung granulomas and highlight α-MSH as a potential novel therapeutic agent for treating pulmonary sarcoidosis.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360058 | PMC |
| http://dx.doi.org/10.1007/s00408-022-00546-x | DOI Listing |
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