In the phase III IMmotion151 trial of metastatic renal cell carcinoma the easy-to-implement modified Glasgow prognostic score predicts outcome more accurately than the IMDC score.

Ann Oncol

Institute of Experimental Oncology, University Medical Center Bonn (UKB), Bonn;; Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn;; Department of Urology and Pediatric Urology, University Medical Center Bonn (UKB), Bonn, Germany. Electronic address:

Published: September 2022

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annonc.2022.06.003DOI Listing

Publication Analysis

Top Keywords

phase iii
4
iii immotion151
4
immotion151 trial
4
trial metastatic
4
metastatic renal
4
renal cell
4
cell carcinoma
4
carcinoma easy-to-implement
4
easy-to-implement modified
4
modified glasgow
4

Similar Publications

The low sulfur selectivity of Fe-based HS-selective catalytic oxidation catalysts is still a problem, especially at a high O content. This is alleviated here through anchoring FeO nanoclusters on UiO-66 via the formation of Fe-O-Zr bonds. The introduced FeO species exist in the form of Fe and Fe.

View Article and Find Full Text PDF

Background: Advanced pancreatic ductal adenocarcinoma (aPDAC) is often accompanied by significant muscle mass loss, contributing to poor prognosis. SarcAPACaP, an ancillary study of the GERCOR-APACaP phase III trial, evaluated the role of adapted physical activity (APA) in aPDAC Western patients receiving first-line chemotherapy. The study aimed to assess (1) the potential impact of computed tomography (CT)-quantified muscle mass before and during treatments on health-related quality of life (HRQoL) and overall survival (OS) and (2) the role of APA in mitigating muscle mass loss.

View Article and Find Full Text PDF

Background: Effects of subthalamic nucleus deep brain stimulation (STN-DBS) on neuropsychiatric symptoms of Parkinson's disease (PD) remain debated. Sensor technology might help to objectively assess behavioural changes after STN-DBS.

Case Presentation: 5 PD patients were assessed 1 before and 5 months after STN-DBS with the Movement Disorders Society Unified Parkinson's Disease Rating Scale part III in the medication ON (plus postoperatively stimulation ON) condition, the Montreal Cognitive Assessment, the Questionnaire for Impulsive-Compulsive Behaviors in Parkinson's Disease Rating Scale present version, the Hospital Anxiety and Depression Scale and the Starkstein Apathy Scale.

View Article and Find Full Text PDF

Background: Immunotherapy has been widely incorporated into the treatment of patients with non-small-cell lung cancer (NSCLC). Many of these patients will experience immune-related adverse events (irAEs) without decreased efficacy. We report a retrospective analysis of the association between irAEs and efficacy outcomes from the BTCRC LUN 16-081 randomized phase 2 trial of consolidation nivolumab (N) plus ipilimumab (IPI) vs N alone following chemoradiotherapy in unresectable Stage IIIA/IIIB NSCLC.

View Article and Find Full Text PDF

Definition and diagnostic criteria of clinical obesity.

Lancet Diabetes Endocrinol

January 2025

Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK; Catholic University of the Sacred Heart, Rome, Italy; University Polyclinic Foundation Agostino Gemelli IRCCS, Rome, Italy.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!