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Genetic variations and clinical significance in young-onset nasopharyngeal cancer: Analysis of EBV interaction with cellular receptor variants and viral glycoproteins.
Heliyon
January 2025
Faculty of Medicine, University of Surabaya, Surabaya, 60292, Indonesia.
Nasopharyngeal cancer (NPC), although rare in young individuals worldwide, is significantly influenced by the Epstein-Barr virus (EBV). Considering EBV's widespread prevalence, understanding its role in NPC's future occurrence, disease progression, clinical symptoms, metastatic tendencies, and prognosis is crucial. In this study, we extensively analyzed two young patients with NPC, who displayed distinct clinical features.
View Article and Find Full Text PDFAnalysis of the risk of death and its associated risk factors in Chinese patients with young-onset type 2 diabetes.
Front Endocrinol (Lausanne)
January 2025
Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, Jiangsu, China.
Objectives: To examine the association between the age at onset of diabetes and the risk of all-cause mortality in a population of individuals diagnosed with type 2 diabetes mellitus (T2DM) and to identify risk factors associated with all-cause mortality in young-onset T2DM (YOD) patients in China.
Methods: This study utilized a cohort of 9759 patients who were diagnosed with T2DM and who were registered and enrolled in the National Basic Public Health Service Management Program in Qinghe District (now Qingjiangpu District) and Huai'an District, Huai'an City, Jiangsu Province, China. The patients were observed from November 2013 to July 2014, and all-cause mortality data were obtained by comprehensive matching with the Huai'an City Resident Mortality Database as of December 31, 2019.
Young-Onset Diabetes in Sri Lanka: Experience From the Developing World.
J Diabetes Res
December 2024
Diabetes & Endocrine Unit, District General Hospital, Nuwara Eliya, Sri Lanka.
Young-onset diabetes (YOD) is characterised by unique diagnostic and management challenges more pronounced in resource-limited settings like Sri Lanka. We aimed to ascertain the prevalence, patterns and characteristics of YOD in Sri Lanka and describe the state of care. Retrospective review of baseline data of all patients enrolled in the prospective multicentre Database for Young-Onset Diabetes, Sri Lanka (DYOD-SL), was performed, from April 2021 to April 2023.
View Article and Find Full Text PDFCardiovascular Complications, Kidney Failure, and Mortality in Young-Onset Type 1 and 2 Diabetes: Data From the Korean National Health Insurance Service.
Diabetes Care
December 2024
Department of Pediatrics, College of Medicine, Seoul St. Mary's Hospital and Catholic University of Korea, Seoul, Republic of Korea.
Article Synopsis
- The study investigates the risks of all-cause mortality and complications related to cardiovascular and renal health in young-onset diabetes patients in South Korea, utilizing a large national health database.
- The research found that individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D) have significantly higher rates of myocardial infarction, stroke, and kidney failure compared to the general population, with particularly alarming statistics for T1D.
- Overall, the findings highlight a critical need for awareness and management of the elevated health risks faced by young people with diabetes in South Korea.
Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease.
Brain Behav
December 2024
Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Background: Sequential working memory refers to the cognitive ability to maintain and/or manipulate a set of ordered representations within a short period. It remains unclear whether sequential working memory is impaired in patients with young onset Parkinson's disease (YOPD).
Objectives: The aim of this study is to evaluate the sequential working memory in patients with YOPD.
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